循环总胆红素、尿苷二磷酸葡萄糖醛酸转移酶 1A1 与非酒精性脂肪性肝病发展的关系：一项横断面研究。
Relationship of circulating total bilirubin, UDP-glucuronosyltransferases 1A1 and the development of non-alcoholic fatty liver disease: a cross-sectional study.
机构信息
Department of Infectious Disease, Qingdao Municipal Hospital, Qingdao University, 1 Jiaozhou Road, Qingdao, 266011, Shandong Province, China.
Department of Laboratory Medicine, Qingdao Municipal Hospital, Qingdao University, Qingdao, 266011, China.
出版信息
BMC Gastroenterol. 2022 Jan 5;22(1):6. doi: 10.1186/s12876-021-02088-7.
BACKGROUND
This study aimed to investigate the correlation of circulating total bilirubin (TB) and UGT1A1 with NAFLD in Chinese Han population.
METHODS
172 adults were enrolled from the Qingdao Municipal Hospital from May 2019 to October 2020. All individuals were examined with MRI-PDFF and divided into no steatosis, mild steatosis, moderate steatosis, and severe steatosis groups according to the MRI-PDFF values. The biochemical indexes and UGT1A1 were measured.
RESULTS
There was no significant difference of circulating TB and UGT1A1 levels between NAFLD group and controls. In the moderate steatosis and severe steatosis groups, the circulating TB levels were higher than that in control group (all P < 0.05). In addition, circulating TB levels were weak positively associated with liver fat fraction in NAFLD patients (ρ = 0.205, P = 0.001). There was no significant correlation between circulating UGT1A1 levels with liver fat fraction in patients with NAFLD (ρ = 0.080, P = 0.179), but positively correlation was found in patients with severe steatosis (ρ = 0.305, P = 0.026).
CONCLUSIONS
The circulating TB levels were significant high in patients with moderate and severe steatosis. Circulating TB levels were weakly associated with liver fat fraction in patients with NAFLD, and the circulating UGT1A1 levels were positively correlated with liver fat fraction in NAFLD patients with severe steatosis.
TRIAL REGISTRATION
ChiCTR, ChiCTR1900022744. Registered 24 April 2019 - Retrospectively registered, http://www.chictr.org.cn/edit.aspx?pid=38304&htm=4 .
背景
本研究旨在探讨中国汉族人群循环总胆红素（TB）和 UGT1A1 与非酒精性脂肪性肝病（NAFLD）的相关性。
方法
2019 年 5 月至 2020 年 10 月，从青岛市立医院招募了 172 名成年人。所有个体均接受 MRI-PDFF 检查，并根据 MRI-PDFF 值分为非脂肪变性组、轻度脂肪变性组、中度脂肪变性组和重度脂肪变性组。测量生化指标和 UGT1A1。
结果
NAFLD 组和对照组之间循环 TB 和 UGT1A1 水平无显著差异。在中度和重度脂肪变性组中，循环 TB 水平高于对照组（均 P<0.05）。此外，循环 TB 水平与 NAFLD 患者的肝脂肪分数呈弱正相关（ρ=0.205，P=0.001）。在 NAFLD 患者中，循环 UGT1A1 水平与肝脂肪分数无显著相关性（ρ=0.080，P=0.179），但在重度脂肪变性患者中存在正相关（ρ=0.305，P=0.026）。
结论
在中重度脂肪变性患者中，循环 TB 水平显著升高。循环 TB 水平与 NAFLD 患者的肝脂肪分数呈弱相关，而在重度脂肪变性的 NAFLD 患者中，循环 UGT1A1 水平与肝脂肪分数呈正相关。
试验注册
ChiCTR，ChiCTR1900022744。注册于 2019 年 4 月 24 日-回顾性注册，http://www.chictr.org.cn/edit.aspx?pid=38304&htm=4。
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