Rajendeeran Anandi, Tenbrock Klaus
RWTH Aachen University, Department of Pediatrics, Pediatric Rheumatology, Pauwelsstr 30, 52074, Aachen, Germany.
J Transl Autoimmun. 2021 Oct 30;4:100130. doi: 10.1016/j.jtauto.2021.100130. eCollection 2021.
Autoimmune diseases are characterized by a failure of tolerance to own body components resulting in tissue damage. Regulatory T cells are gatekeepers of tolerance. This review focusses on the function and pathophysiology of regulatory T cells in the context of autoimmune diseases including rheumatoid and juvenile idiopathic arthritis as well as systemic lupus erythematosus with an overview over current and future therapeutic options to boost Treg function.
自身免疫性疾病的特征是对自身身体成分的耐受性失效,从而导致组织损伤。调节性T细胞是耐受性的守门人。本综述聚焦于调节性T细胞在自身免疫性疾病背景下的功能和病理生理学,包括类风湿性关节炎和青少年特发性关节炎以及系统性红斑狼疮,并概述了当前和未来增强调节性T细胞功能的治疗选择。