碳点修饰的TiO纳米棒阵列在钛表面的体外和体内高效抗菌活性
In vitro and in vivo highly effective antibacterial activity of carbon dots-modified TiO nanorod arrays on titanium.
作者信息
He Dongmei, Zhang Xiangyu, Yao Xiaohong, Yang Yongqiang
机构信息
Laboratory of Biomaterial Surfaces & Interfaces, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
Laboratory of Biomaterial Surfaces & Interfaces, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China; College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China; Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
出版信息
Colloids Surf B Biointerfaces. 2022 Mar;211:112318. doi: 10.1016/j.colsurfb.2022.112318. Epub 2022 Jan 6.
Light-triggered antibacterial therapy has been proven to be a secure and effective way to treat bacterial infection. Nevertheless, the long-term security of the common photosensitizer remains to be seen in the body. In this work, carbon dots (CDs) with good biocompatibility are incorporated into TiO nanorods to improve the photocatalytic and photothermal ability of titanium implants under the irradiation of visible light (VL) and near-infrared (NIR) light. The C-TiO NR exhibit excellent in vitro and in vivo antimicrobial effect under 660 nm VL and 808 nm NIR light co-irradiation owing to the combined effect of hyperthermia, reactive oxygen species (ROS) and nanorod structure. Besides, C-TiO NR can improve the adhesion and diffusion of bone marrow mesenchymal stem cells (BMSCs).
光触发抗菌疗法已被证明是治疗细菌感染的一种安全有效的方法。然而，常见光敏剂在体内的长期安全性仍有待观察。在这项工作中，具有良好生物相容性的碳点（CDs）被掺入TiO纳米棒中，以提高钛植入物在可见光（VL）和近红外（NIR）光照射下的光催化和光热能力。由于热疗、活性氧（ROS）和纳米棒结构的综合作用，C-TiO NR在660 nm VL和808 nm NIR光共照射下表现出优异的体外和体内抗菌效果。此外，C-TiO NR可以改善骨髓间充质干细胞（BMSCs）的黏附和扩散。
Zotero 插件