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基于 DNA 马达的功能体系的最新进展。

Recent Progress in DNA Motor-Based Functional Systems.

机构信息

Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, 100084, PR China.

Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China.

出版信息

ACS Appl Bio Mater. 2021 Mar 15;4(3):2251-2261. doi: 10.1021/acsabm.0c01540. Epub 2021 Feb 17.

Abstract

The designability, functionalization, and diverse secondary structures of DNA enable the construction of DNA motors with stimuli-responsiveness. Therefore, it has been widely used to fabricate functional systems or generate mechanical power under external stimuli, such as pH, light, heat, electrical, and chemical molecular signals. Furthermore, the DNA motor has also been demonstrated to promote the applications of smart devices and materials, particularly in controllable drug delivery and reversible molecular switching. In this review, we have summarized and discussed recent progress of the construction and applications of DNA motor-based functional systems, such as responsive nanodevices, modified surfaces, and hydrogels.

摘要

DNA 的设计性、功能化和多样的二级结构使具有刺激响应性的 DNA 马达得以构建。因此,它已被广泛用于在外部刺激(如 pH 值、光、热、电和化学分子信号)下制造功能系统或产生机械动力。此外,DNA 马达还被证明可以促进智能设备和材料的应用,特别是在可控药物输送和可逆分子开关方面。在这篇综述中,我们总结和讨论了基于 DNA 马达的功能系统的构建和应用的最新进展,如响应性纳米器件、修饰表面和水凝胶。

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