一种使用 N-异丙基-(碘 123)p-碘安非他明对脑血流量进行的新型非侵入性定量评估。
A new noninvasive quantitative assessment of cerebral blood flow using N-isopropyl-(iodine 123)p-iodoamphetamine.
作者信息
Matsuda H, Higashi S, Tsuji S, Seki H, Sumiya H, Fujii H, Oba H, Terada H, Imai K, Tonami N
机构信息
Department of Nuclear Medicine, School of Medicine, Kanazawa University, Japan.
出版信息
Am J Physiol Imaging. 1987;2(2):49-55.
The use of a nomogram is described as a new noninvasive quantitative assessment of cerebral blood flow using N-isopropyl-(123I)p-iodoamphetamine (IMP) and single-photon emission computed tomography. The nomogram was constructed from a computer analysis of the flow value relative to varying washout rate of brain activities between early and late tomographic images, and partition coefficient between brain tissue and blood. The validity of this method was evaluated in normal volunteers and in patients with cerebrovascular disorders by comparing the cortical flow values (Y) estimated from the IMP-nomogram with initial slope indices (X) by the 133Xe inhalation method. A significant correlation (N = 42, r = 0.88, P less than .001) was demonstrated between them, and the regression line was Y = 1.6X-7. A development and confirmation of this method made it possible to measure flow values noninvasively with the use of IMP.
一种列线图的应用被描述为使用N-异丙基-(123I)p-碘安非他明（IMP）和单光子发射计算机断层扫描对脑血流量进行新的无创定量评估。该列线图是通过对早期和晚期断层图像之间脑活动的不同洗脱率以及脑组织与血液之间的分配系数的流量值进行计算机分析构建而成。通过将IMP列线图估计的皮质流量值（Y）与133Xe吸入法的初始斜率指数（X）进行比较，在正常志愿者和脑血管疾病患者中评估了该方法的有效性。两者之间显示出显著相关性（N = 42，r = 0.88，P小于0.001），回归线为Y = 1.6X - 7。这种方法的开发和验证使得使用IMP能够无创地测量流量值。
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