CTRP3 作为沙特自闭症儿童血浆中的一种新型生物标志物。
CTRP3 as a novel biomarker in the plasma of Saudi children with autism.
机构信息
Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.
Autism Research and Treatment Center, Riyadh, Saudi Arabia.
出版信息
PeerJ. 2022 Jan 11;10:e12630. doi: 10.7717/peerj.12630. eCollection 2022.
BACKGROUND
C1q/tumor necrosis factor-related protein-3 (CTRP3) has diverse functions: anti-inflammation, metabolic regulation, and protection against endothelial dysfunction.
METHODS
The plasma level of CTRP3 in autistic patients ( = 32) was compared to that in controls ( = 37) using ELISA.
RESULTS
CTRP3 was higher (24.7% with < 0.05) in autistic patients than in controls. No association was observed between CTRP3 and the severity of the disorder using the Childhood Autism Rating Scale (CARS). A positive correlation between CARs and the age of patients was reported. Receiver operating characteristic (ROC) analysis demonstrated a low area under the curve (AUC) for all patients (0.636). Low AUCs were also found in the case of severe patients (0.659) compared to controls, but both values were statistically significant ( ≤ 0.05). Despite the small sample size, we are the first to find an association between CTRP3 and autism spectrum disorder (ASD).
背景
C1q/肿瘤坏死因子相关蛋白-3（CTRP3）具有多种功能：抗炎、代谢调节和保护内皮功能障碍。
方法
采用 ELISA 法比较自闭症患者（n=32）和对照组（n=37）的血浆 CTRP3 水平。
结果
自闭症患者的 CTRP3 水平较高（24.7%，<0.05）。使用儿童自闭症评定量表（CARS），未观察到 CTRP3 与疾病严重程度之间的相关性。报告了 CARs 与患者年龄之间的正相关关系。受试者工作特征（ROC）分析显示，所有患者的曲线下面积（AUC）均较低（0.636）。与对照组相比，严重患者的 AUC 也较低（0.659），但两者均有统计学意义（≤0.05）。尽管样本量较小，但我们是第一个发现 CTRP3 与自闭症谱系障碍（ASD）之间存在关联的。
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