Hirschelmann R, Bekemeier H
Department of Pharmacology, Martin Luther University Halle-Wittenberg, DDR.
Free Radic Res Commun. 1986;2(1-2):125-7. doi: 10.3109/10715768609088063.
The carrageenin rat paw edema was dose-dependently inhibited by i.v. and i.m. administration of desferrioxamine, a specific iron chelating agent. Therefore, iron-catalyzed formation of free radicals might be involved in this acute inflammatory reaction. In contrast, no antiinflammatory activity of desferrioxamine could be seen in rat adjuvant arthritis, a model of subacute and chronic inflammation.
特异性铁螯合剂去铁胺静脉注射和肌肉注射对角叉菜胶所致大鼠足爪水肿有剂量依赖性抑制作用。因此，铁催化的自由基形成可能参与了这种急性炎症反应。相比之下，在大鼠佐剂性关节炎（一种亚急性和慢性炎症模型）中未观察到去铁胺的抗炎活性。
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