Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, 72076 Tubingen, Germany.
Cluster of Excellence EXC 2124 "Controlling Microbes to Fight Infections", University of Tübingen, Elfriede-Aulhorn-Str. 6, 72076 Tubingen, Germany.
Genes (Basel). 2021 Dec 23;13(1):34. doi: 10.3390/genes13010034.
encodes 16 two-component systems (TCSs) that enable the bacteria to sense and respond to changing environmental conditions. Considering the function of these TCSs in bacterial survival and their potential role as drug targets, it is important to understand the exact mechanisms underlying signal perception. The differences between the sensing of appropriate signals and the transcriptional activation of the TCS system are often not well described, and the signaling mechanisms are only partially understood. Here, we review present insights into which signals are sensed by histidine kinases in to promote appropriate gene expression in response to diverse environmental challenges.
编码 16 个双组分系统 (TCSs)，使细菌能够感知和响应不断变化的环境条件。考虑到这些 TCS 在细菌生存中的功能及其作为药物靶点的潜在作用，了解信号感知的确切机制非常重要。适当信号的感知与 TCS 系统的转录激活之间的差异通常描述得不够好，而且信号机制也只是部分理解。在这里，我们回顾了目前对哪些信号被感应到的见解，以促进在应对各种环境挑战时适当的基因表达。
