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坚持 MIND 饮食与成年人心血管疾病风险:一项队列研究。

Adherence to the MIND diet and the risk of cardiovascular disease in adults: a cohort study.

机构信息

Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Food Funct. 2022 Feb 7;13(3):1651-1658. doi: 10.1039/d1fo02069b.

Abstract

The Mediterranean-DASH intervention for neurodegenerative delay (MIND) and cardiovascular disease (CVD) has yet to be studied. As a result, the objective of this study was to investigate if there was a link between MIND diet adherence and the risk of CVD in adults over a 10.6-year period of time. There were 2863 participants in this research cohort who were free of CVD and were followed-up for 10.6 years. Using a validated food frequency questionnaire (FFQ), the MIND diet score was calculated. Reliable medical data was used to evaluate cardiovascular events, including coronary heart disease (CHD), stroke, and CVD-related mortality. A total of 200 CVD occurrences (159 CHD, 21 stroke, and 20 CVD fatalities) were documented throughout the 10.6-year follow-up period. Our results indicated each increase in MIND diet score reduced the incidence of CVD by 16% (HR: 0.84; 95% CI: 0.74 to 0.96). We also detected an inverse association relationship between the MIND diet and the incidence of CVD after classifying the MIND diet score into tertiles as well (HR: 0.68; 95% CI: 0.47 to 0.97). Among the components of the MIND diet, each increase in whole grains, green leafy vegetables, and beans reduced the risk of CVD by 60%, 45%, and 65%, respectively. Finally, our findings revealed that the higher adherence to the MIND was associated with a lower risk of cardiovascular events. Besides, we found an inverse association between consumption of whole grains, green leafy vegetables, and beans and the number of CVD incidents. However, more well-designed cohort studies are needed before conclusive conclusions can be formed.

摘要

地中海-得舒饮食干预神经退行性疾病(MIND)和心血管疾病(CVD)尚未进行研究。因此,本研究旨在探讨 MIND 饮食依从与成年人 CVD 风险之间是否存在关联,研究时间为 10.6 年。该研究队列纳入了 2863 名无 CVD 病史且随访时间为 10.6 年的参与者。使用经过验证的食物频率问卷(FFQ)计算 MIND 饮食评分。采用可靠的医疗数据评估心血管事件,包括冠心病(CHD)、中风和 CVD 相关死亡率。在 10.6 年的随访期间,共记录了 200 例 CVD 发病事件(159 例 CHD、21 例中风和 20 例 CVD 死亡)。结果表明,MIND 饮食评分每增加 1 分,CVD 发病率降低 16%(HR:0.84;95%CI:0.74 至 0.96)。我们还发现,将 MIND 饮食评分分为三分位数后,MIND 饮食与 CVD 发病率之间也存在负相关关系(HR:0.68;95%CI:0.47 至 0.97)。在 MIND 饮食的组成部分中,全谷物、绿叶蔬菜和豆类的摄入量每增加 1 份,CVD 的风险分别降低 60%、45%和 65%。最后,我们的研究结果表明,更高的 MIND 饮食依从性与较低的心血管事件风险相关。此外,我们发现全谷物、绿叶蔬菜和豆类的摄入量与 CVD 发病次数呈负相关。然而,还需要更多设计良好的队列研究来得出结论。

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