欧陆蒲桃 A-D，四种来自桉树的具有抗菌作用的甲酰基间苯三酚类倍半萜。
Eurobusones A-D, four antibacterial formyl phloroglucinol meoterpenoids from Eucalyptus robusta.
机构信息
Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China..
出版信息
Fitoterapia. 2022 Mar;157:105131. doi: 10.1016/j.fitote.2022.105131. Epub 2022 Jan 31.
Four antibacterial formyl phloroglucinol meroterpenoids (FPMs), eurobusones A-D (1-4), as well as six known analogues (5-10), were isolated from the leaves of Eucalyptus robusta. Their structures were determined by the analysis of spectroscopic data and electron circular dichroism (ECD) calculation, along with the application of Snatzke helicity rules. Among them, compounds 2 and 8-10 showed good activity against Staphylococcus aureus, Pseudomonas aeruginosa and Bacillus subtilis with MIC values less than 1.00 μg/mL.
从桉树的叶子中分离出四种抗菌甲酰基苯并呋喃类倍半萜化合物（FPMs），即 eurobusones A-D（1-4），以及六种已知的类似物（5-10）。通过分析光谱数据和电子圆二色性（ECD）计算，并应用 Snatzke 螺旋规则确定了它们的结构。其中，化合物 2 和 8-10 对金黄色葡萄球菌、铜绿假单胞菌和枯草芽孢杆菌表现出良好的活性，MIC 值均小于 1.00μg/mL。
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