原发性纤毛运动障碍患儿下呼吸道一氧化氮水平与中性粒细胞炎症有关。
Lower Airway Nitrogen Oxide Levels in Children with Primary Ciliary Dyskinesia Is Linked to Neutrophilic Inflammation.
机构信息
Division of Respiratory Medicine, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada; Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada.
Division of Respiratory Medicine, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada.
出版信息
J Pediatr. 2022 May;244:230-233. doi: 10.1016/j.jpeds.2022.01.040. Epub 2022 Feb 2.
Treatment of primary ciliary dyskinesia pulmonary exacerbations resulted in an increase in sputum nitric oxide (NO) metabolites and decrease in neutrophilic inflammation. The association between the 2 suggests that neutrophilic inflammation contributes to airway NO deficiency in primary ciliary dyskinesia and that reducing inflammation may lead to improved airway NO homeostasis. TRIAL REGISTRY: ClinicalTrials.gov: NCT01155115.
原发性纤毛运动障碍性肺恶化的治疗导致痰一氧化氮（NO）代谢物增加和中性粒细胞炎症减少。这两者之间的关联表明，中性粒细胞炎症导致原发性纤毛运动障碍的气道 NO 缺乏，并且减少炎症可能导致改善气道 NO 动态平衡。临床试验注册：ClinicalTrials.gov：NCT01155115。
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