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癌症中的含α9烟碱受体

α9-Containing Nicotinic Receptors in Cancer.

作者信息

Pucci Susanna, Zoli Michele, Clementi Francesco, Gotti Cecilia

机构信息

Institute of Neuroscience, National Research Council (CNR), Milan, Italy.

NeuroMi Milan Center for Neuroscience, University of Milano Bicocca, Milan, Italy.

出版信息

Front Cell Neurosci. 2022 Jan 21;15:805123. doi: 10.3389/fncel.2021.805123. eCollection 2021.

DOI:10.3389/fncel.2021.805123
PMID:35126059
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8814915/
Abstract

Neuronal nicotinic acetylcholine receptors containing the α9 or the α9 and α10 subunits are expressed in various extra-neuronal tissues. Moreover, most cancer cells and tissues highly express α9-containing receptors, and a number of studies have shown that they are powerful regulators of responses that stimulate cancer processes such as proliferation, inhibition of apoptosis, and metastasis. It has also emerged that their modulation is a promising target for drug development. The aim of this review is to summarize recent data showing the involvement of these receptors in controlling the downstream signaling cascades involved in the promotion of cancer.

摘要

含有α9或α9与α10亚基的神经元烟碱型乙酰胆碱受体在多种神经元外组织中表达。此外，大多数癌细胞和组织高度表达含α9的受体，并且多项研究表明，它们是刺激癌症进程（如增殖、抑制细胞凋亡和转移）的反应的有力调节因子。还发现对它们的调节是药物开发的一个有前景的靶点。本综述的目的是总结近期数据，这些数据表明这些受体参与调控促进癌症的下游信号级联反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1e3/8814915/3536c02f3ae9/fncel-15-805123-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1e3/8814915/3536c02f3ae9/fncel-15-805123-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1e3/8814915/3536c02f3ae9/fncel-15-805123-g0001.jpg

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