Nivel-PCD数据库和SIDIAP数据库中与抗抑郁药处方相关的适应症。

Indications related to antidepressant prescribing in the Nivel-PCD database and the SIDIAP database.

作者信息

Camacho-Arteaga L F, Gardarsdottir H, Ibañez L, Souverein P C, van Dijk L, Hek K, Vidal X, Ballarín E, Sabaté M

机构信息

Department of Pharmacology, Therapeutics and Toxicology, Autonomous University of Barcelona, Spain; Clinical Pharmacology Department, Vall d'Hebron University Hospital, Passeig Vall d'Hebron 119-129, Barcelona 08035, Spain; Clinical Pharmacology, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Spain.

Division of Pharmacoepidemiology and Clinical Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, the Netherland; Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht, the Netherland; Department of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland.

出版信息

J Affect Disord. 2022 Apr 15;303:131-137. doi: 10.1016/j.jad.2022.02.001. Epub 2022 Feb 5.

DOI:10.1016/j.jad.2022.02.001

PMID:35134393

Abstract

BACKGROUND

Antidepressant drug consumption has increased, mainly in the elderly. This trend could be explained by the use for indications other than depression. We aimed to describe the indications related to antidepressant drug new users in two primary care settings.

METHODS

A longitudinal study of new antidepressant users aged ≥65 was conducted, with data from the Nivel-PCD (The Netherlands) and SIDIAP (Catalonia) databases (2010-2015). As a proxy for indication, diagnoses registered around the 3 months of antidepressant prescribing were collected. Indications were classified in seven categories and an additional one of non-selected indications. The percentage and incidence calculated over the total population registered was described.

RESULTS

A total of 16,537 and 199,168 new antidepressant users were identified in the Nivel-PCD and SIDIAP databases, respectively (women aged 65-69 were the most prevalent). Depression was the most frequent indication (24.0% and 31.3%), followed by anxiety (12.5% and 19.5%) and sleep disorders (10.2% and 26.4%). Tricyclic antidepressants were the most commonly prescribed in Nivel-PCD (48.7%), mainly associated with neuropathic pain, and selective serotonin reuptake inhibitor antidepressants in SIDIAP (63.1%), associated with depression. The non-selected indications category showed an upward trend in the Nivel-PCD database while in the SIDIAP database it decreased.

LIMITATIONS

It is not mandatory for physicians to register a diagnosis with each prescription.

CONCLUSIONS

Depression was the most common prescribing indication in The Netherlands and Spain, followed by anxiety and sleep disorders. The most commonly prescribed antidepressant differed between the countries and is likely explained by differences in local guidelines.

摘要

背景

抗抑郁药物的消费量有所增加，主要是在老年人中。这种趋势可能是由于用于抑郁症以外的适应症。我们旨在描述在两个初级保健机构中与新使用抗抑郁药物者相关的适应症。

方法

对年龄≥65岁的新使用抗抑郁药物者进行了一项纵向研究，数据来自Nivel-PCD（荷兰）和SIDIAP（加泰罗尼亚）数据库（2010 - 2015年）。作为适应症的替代指标，收集了抗抑郁药物处方开具前约3个月登记的诊断信息。适应症分为七类以及一个未选定适应症类别。描述了在登记的总人口中计算出的百分比和发病率。

结果

在Nivel-PCD和SIDIAP数据库中分别确定了16537名和199168名新使用抗抑郁药物者（65 - 69岁女性最为普遍）。抑郁症是最常见的适应症（分别为24.0%和31.3%），其次是焦虑症（12.5%和19.5%）和睡眠障碍（10.2%和26.4%）。三环类抗抑郁药在Nivel-PCD中是最常开具的药物（48.7%），主要与神经性疼痛相关，而选择性5-羟色胺再摄取抑制剂类抗抑郁药在SIDIAP中最为常见（63.1%），与抑郁症相关。未选定适应症类别在Nivel-PCD数据库中呈上升趋势，而在SIDIAP数据库中则下降。