焦亡及其在糖尿病心肌病中的调节
Pyroptosis and Its Regulation in Diabetic Cardiomyopathy.
作者信息
Lu Yafang, Lu Yaqiong, Meng Jun, Wang Zuo
机构信息
Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical College, University of South China, Hengyang, China.
Functional Department, The First Affiliated Hospital, University of South China, Hengyang, China.
出版信息
Front Physiol. 2022 Jan 25;12:791848. doi: 10.3389/fphys.2021.791848. eCollection 2021.
Abstract
Diabetic cardiomyopathy (DbCM) is a prevalent disease, characterized by contractile dysfunction and left ventricular hypertrophy. Patients with DbCM have high morbidity and mortality worldwide. Recent studies have identified that pyroptosis, a kind of cell death, could be induced by hyperglycemia involved in the formation of DbCM. This review summarizes the regulatory mechanisms of pyroptosis in DbCM, including NOD-like receptor3, AIM2 inflammasome, long non-coding RNAs, microRNAs, circular RNA, autophagy, and some drugs.
摘要
糖尿病性心肌病（DbCM）是一种常见疾病，其特征为收缩功能障碍和左心室肥厚。全球范围内，DbCM患者的发病率和死亡率都很高。最近的研究发现，一种细胞死亡形式——焦亡，可能由参与DbCM形成的高血糖诱导。本综述总结了焦亡在DbCM中的调控机制，包括NOD样受体3、AIM2炎性小体、长链非编码RNA、微小RNA、环状RNA、自噬以及一些药物。
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