基于腙键开关的比率型 pH 响应 F 型磁共振成像造影剂。
Ratiometric pH-Responsive F Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switches.
机构信息
Department of Chemical Organic Technology and Petrochemistry, Silesian University of Technology Krzywoustego 4,44-100 Gliwice, Poland.
Institute of Nuclear Physics Polish Academy of Sciences, 31-342 Krakow, Poland.
出版信息
Anal Chem. 2022 Mar 1;94(8):3427-3431. doi: 10.1021/acs.analchem.1c04978. Epub 2022 Feb 14.
Hydrazone-based molecular switches serve as efficient ratiometric pH-sensitive agents that can be tracked with F NMR/MRI and H NMR. Structural changes induced between pH 3 and 4 lead to signal appearance and disappearance at H and F NMR spectra allowing ratiometric pH measurements. The most pronounced are resonances of the CF group shifted by 1.8 ppm with F NMR and a hydrazone proton shifted by 2 ppm with H NMR.
基于腙的分子开关可用作高效的比率型 pH 敏感试剂，可通过 F NMR/MRI 和 H NMR 进行跟踪。在 pH 3 和 4 之间引起的结构变化导致在 H 和 F NMR 光谱中出现和消失信号，从而实现比率型 pH 测量。最明显的是 F NMR 中 CF 基团的共振位移 1.8 ppm，以及 H NMR 中腙质子的共振位移 2 ppm。
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