双环（烷基）（氨基）卡宾（BICAAC）作为一种无金属催化剂，用于将腈还原为胺。
Bicyclic (alkyl)(amino)carbene (BICAAC) as a metal-free catalyst for reduction of nitriles to amines.
机构信息
Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur Campus, Nadia, 741246, West Bengal, India.
出版信息
Chem Commun (Camb). 2022 Mar 1;58(18):3047-3050. doi: 10.1039/d1cc06962d.
PMID:35156960
Abstract
Bicyclic (alkyl)(amino)carbene (BICAAC) is introduced as a metal-free catalyst for the reduction of various nitriles to the corresponding amine hydrochloride salts in the presence of pinacolborane. Mechanistic investigations combining experiments and DFT calculations suggest a B-H addition to the carbene center, which acts as a carrier of the hydride source.
摘要
双环（烷基）（氨基）卡宾（BICAAC）作为一种无金属催化剂，在频哪醇硼烷的存在下，将各种腈还原为相应的胺盐酸盐。结合实验和密度泛函理论（DFT）计算的机理研究表明，B-H 加成到卡宾中心，该中心充当氢源载体。
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