Wang Nanying, Chen Yannan, Song Yukun, Yu Deyang, Tan Mingqian
Academy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Qinggongyuan1, Gangjingzi District, Dalian 116034, China.
National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, China.
Foods. 2022 Jan 24;11(3):308. doi: 10.3390/foods11030308.
Calcium is considered as an important nutrient element for the maintenance of human health, and food-borne nanoparticles (FNs) produced during food processing may have potential as nanocarriers for calcium ion delivery. Beef is an important source of animal protein that has high protein and low fat content and is rich in a variety of amino acids; thus, beef may be a suitable material for the development of calcium nanocarriers. In this paper, FNs were synthesized from beef by one-step hydrothermal synthesis. The FNs had a spherical shape with a size of about 3.0 nm and emitted a bright blue fluorescence under 365 nm ultraviolet irradiation. The amino nitrogen atom and carboxyl oxygen atom of the functional groups on the surface of the FNs were the main binding sites for the chelation of Ca(II). The size of the FNs-Ca(II) complex was about 4.75 nm, and the specific signal peak of calcium at 3.7 keV was observed in its energy dispersive X-ray spectroscopy spectrum. The viability of cells treated with FNs-Ca(II) was more than 65%, while viability was only 60% after treatment with CaCl. The results showed that the FNs from beef have great potential in calcium delivery for the development of a calcium supplement.
钙被认为是维持人体健康的重要营养元素，食品加工过程中产生的食品源性纳米颗粒（FNs）可能具有作为钙离子递送纳米载体的潜力。牛肉是动物蛋白的重要来源，蛋白质含量高、脂肪含量低，且富含多种氨基酸；因此，牛肉可能是开发钙纳米载体的合适材料。本文采用一步水热合成法从牛肉中合成了FNs。FNs呈球形，尺寸约为3.0 nm，在365 nm紫外光照射下发出亮蓝色荧光。FNs表面官能团的氨基氮原子和羧基氧原子是与Ca(II)螯合的主要结合位点。FNs-Ca(II)复合物的尺寸约为4.75 nm，在其能量色散X射线光谱图中观察到3.7 keV处钙的特定信号峰。用FNs-Ca(II)处理的细胞活力超过65%，而用CaCl处理后的活力仅为60%。结果表明，来自牛肉的FNs在开发钙补充剂的钙递送方面具有巨大潜力。
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