喷墨打印在薄聚对二甲苯薄膜上的柔性脑电（ECoG）微电极阵列。
An Inkjet Printed Flexible Electrocorticography (ECoG) Microelectrode Array on a Thin Parylene-C Film.
机构信息
American Dental Association Science & Research Institute, Gaithersburg, MD 20899, USA.
Department of Electrical and Computer Engineering, University of Texas Rio Grande Valley, Edinburg, TX 78539, USA.
出版信息
Sensors (Basel). 2022 Feb 8;22(3):1277. doi: 10.3390/s22031277.
Electrocorticography (ECoG) is a conventional, invasive technique for recording brain signals from the cortical surface using an array of electrodes. In this study, we developed a highly flexible 22-channel ECoG microelectrode array on a thin Parylene film using novel fabrication techniques. Narrow (<40 µm) and thin (<500 nm) microelectrode patterns were first printed on PDMS, then the patterns were transferred onto Parylene films via vapor deposition and peeling. A custom-designed, 3D-printed connector was built and assembled with the Parylene-based flexible ECoG microelectrode array without soldering. The impedance of the assembled ECoG electrode array was measured in vitro by electrochemical impedance spectroscopy, and the result was consistent. In addition, we conducted in vivo studies by implanting the flexible ECoG sensor in a rat and successfully recording brain signals.
脑皮层电图（ECoG）是一种常规的、有创的技术，通过使用电极阵列从皮层表面记录脑信号。在这项研究中，我们使用新颖的制造技术在薄的聚对二甲苯薄膜上开发了一种高度灵活的 22 通道 ECoG 微电极阵列。首先，将窄（<40 µm）和薄（<500 nm）的微电极图案打印在 PDMS 上，然后通过气相沉积和剥离将图案转移到聚对二甲苯薄膜上。定制设计的 3D 打印连接器与基于聚对二甲苯的柔性 ECoG 微电极阵列组装在一起，无需焊接。通过电化学阻抗谱在体外测量组装好的 ECoG 电极阵列的阻抗，结果是一致的。此外，我们通过将柔性 ECoG 传感器植入大鼠体内进行了体内研究，并成功地记录了脑信号。
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