Department of Neurology, University of Alabama at Birmingham, 1720 2nd Ave. South, SC271, Birmingham, AL, 35294-0017, USA.
J Neurovirol. 2022 Feb;28(1):158-161. doi: 10.1007/s13365-022-01056-5. Epub 2022 Feb 18.
Symptoms of autonomic dysfunction, particularly those of orthostatic intolerance, continue to represent a major component of the currently recognized post-acute sequelae of SARS-CoV-2 infections. Different pathophysiologic mechanisms can be involved in the development of orthostatic intolerance including hypovolemia due to gastrointestinal dysfunction, fatigue-associated deconditioning, and hyperadrenergic state due to pandemic-related anxiety. Additionally, there has been a well-established association of a common primary autonomic disorder like postural orthostatic tachycardia syndrome, a subtype of orthostatic intolerance, with antecedent viral infections. Here we report a case of neuropathic type postural orthostatic tachycardia syndrome as a form of autonomic neuropathy that developed following COVID-19 infection.
自主神经功能障碍的症状，特别是直立不耐受的症状，仍然是目前公认的 SARS-CoV-2 感染后急性后遗症的主要组成部分。直立不耐受的发展可能涉及不同的病理生理机制，包括胃肠道功能障碍导致的血容量减少、与疲劳相关的适应性下降，以及大流行相关焦虑导致的高肾上腺素能状态。此外，已经确立了一种常见的原发性自主神经障碍（如体位性心动过速综合征，一种直立不耐受的亚型）与先前的病毒感染之间存在关联。在这里，我们报告了一例神经型体位性心动过速综合征，这是一种自主神经病变的形式，发生在 COVID-19 感染之后。
