埃塞俄比亚早产儿出生窒息的决定因素：系统评价和观察性研究方案的荟萃分析。

Determinants of birth asphyxia among preterm newborns in Ethiopia: a systematic review and meta-analysis of observational studies protocol.

机构信息

College of Medicine and Health Sciences, Samara University, Samara, Afar Region, Ethiopia.

Dream Science and Technology College, Dessie, Ethiopia.

出版信息

Syst Rev. 2022 Feb 19;11(1):30. doi: 10.1186/s13643-022-01905-8.

DOI:10.1186/s13643-022-01905-8

PMID:35183266

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8858466/

Abstract

BACKGROUND

Birth asphyxia accounted for nearly 50% of neonatal mortality in Sub-Saharan African countries. This scenario has been worst in Ethiopia where every two out of three deaths attributed to birth asphyxia. Moreover, studies conducted in Ethiopia were highly variable and inconclusive to estimate the pooled prevalence and determinants of perinatal birth asphyxia among preterm babies.

OBJECTIVE

This study aimed to estimate the pooled prevalence of birth asphyxia and its determinants among preterm newborns in Ethiopia.

METHODS

The protocol for this review is registered at PROSPERO with registration number CRD42020158224. A comprehensive online databases (PubMed, HINARI, Scopus, EMBASE, Science direct, and Cochrane library database), Google Scholar, African Journals online, other gray and online repository accessed studies will be searched using different search engines. In addition, maternity and infant care databases uploaded at Ethiopian Health Development Journal and Ethiopian Journal of Health Sciences will be searched until 30 June 2020. Newcastle-Ottawa Quality Assessment Scale (NOS) will be used for critical appraisal of studies. Three reviewers will screen all retrieved articles, conduct data extraction, and then critically appraise all identified studies. All identified observational studies reporting the prevalence of birth asphyxia and associated factors among neonates in Ethiopia will be considered. The analysis of data will be done using STATA 11.0. We will demonstrate pooled estimates and determinants of birth asphyxia with effect size and 95% confidence interval. Heterogeneity among the included studies will be assessed through the Cochrane Q test statistics and I test. Publication bias will be checked using funnel plot and Egger's test. Finally, statistical significance level will be declared at a p value of less than 0.05.

DISCUSSION

The result from this systematic review will inform and guide health policy planners to invest limited resources on maternal and neonatal health. Furthermore, it will be a stimulus for future cumulative meta-analysis researchers in developing nations.

摘要

背景

在撒哈拉以南非洲国家，出生窒息占新生儿死亡的近 50%。在埃塞俄比亚，这种情况最为严重，每三个死亡婴儿中就有两个归因于出生窒息。此外，在埃塞俄比亚进行的研究差异很大，结果也不一致，无法估计早产儿围产期出生窒息的 pooled prevalence 和决定因素。

目的

本研究旨在估计埃塞俄比亚早产儿出生窒息的 pooled prevalence 及其决定因素。

方法

本综述的方案已在 PROSPERO 注册，注册编号为 CRD42020158224。将使用不同的搜索引擎在综合在线数据库（PubMed、HINARI、Scopus、EMBASE、Science direct 和 Cochrane library 数据库）、Google Scholar、African Journals online、其他灰色和在线存储库中检索研究。此外，还将在埃塞俄比亚卫生发展杂志和埃塞俄比亚卫生科学杂志上上传的产妇和婴儿护理数据库进行检索，检索截止日期为 2020 年 6 月 30 日。将使用纽卡斯尔-渥太华质量评估量表（NOS）对研究进行批判性评价。三名审查员将筛选所有检索到的文章，进行数据提取，然后对所有确定的研究进行批判性评价。所有符合条件的观察性研究都将报告埃塞俄比亚新生儿出生窒息的 prevalence 和相关因素。将使用 STATA 11.0 分析数据。我们将用效应大小和 95%置信区间展示出生窒息的 pooled estimate 和决定因素。通过 Cochrane Q 检验统计量和 I 检验评估纳入研究之间的异质性。通过漏斗图和 Egger 检验检查发表偏倚。最后，将以 p 值小于 0.05 作为统计显著性水平。