Department of Plant and Soil Science, Fiber and Biopolymer Research Institute, Texas Tech University, Lubbock, TX 79403, USA.
Department of Textile Engineering, University of South Asia, Dhaka, 1213, Bangladesh.
Chem Rec. 2022 Jul;22(7):e202100319. doi: 10.1002/tcr.202100319. Epub 2022 Feb 21.
Recently, nanostructured carbon-based soft bioelectronics and biosensors have received tremendous attention due to their outstanding physical and chemical properties. The ultrahigh specific surface area, high flexibility, lightweight, high electrical conductivity, and biocompatibility of 1D and 2D nanocarbons, such as carbon nanotubes (CNT) and graphene, are advantageous for bioelectronics applications. These materials improve human life by delivering therapeutic advancements in gene, tumor, chemo, photothermal, immune, radio, and precision therapies. They are also utilized in biosensing platforms, including optical and electrochemical biosensors to detect cholesterol, glucose, pathogenic bacteria (e. g., coronavirus), and avian leucosis virus. This review summarizes the most recent advancements in bioelectronics and biosensors by exploiting the outstanding characteristics of nanocarbon materials. The synthesis and biocompatibility of nanocarbon materials are briefly discussed. In the following sections, applications of graphene and CNTs for different therapies and biosensing are elaborated. Finally, the key challenges and future perspectives of nanocarbon materials for biomedical applications are highlighted.
最近,由于其出色的物理和化学性质,基于纳米结构的碳基软生物电子学和生物传感器受到了极大的关注。一维和二维纳米碳,如碳纳米管(CNT)和石墨烯,具有超高的比表面积、高柔韧性、重量轻、高导电性和生物相容性,有利于生物电子学应用。这些材料通过在基因、肿瘤、化疗、光热、免疫、放射和精准治疗方面提供治疗进展,改善了人类的生活。它们还被用于生物传感平台,包括光学和电化学生物传感器,以检测胆固醇、葡萄糖、致病性细菌(例如冠状病毒)和禽白血病病毒。本综述通过利用纳米碳材料的卓越特性,总结了生物电子学和生物传感器的最新进展。简要讨论了纳米碳材料的合成和生物相容性。在接下来的几节中,详细阐述了石墨烯和 CNT 在不同治疗和生物传感中的应用。最后,强调了纳米碳材料在生物医学应用中的关键挑战和未来展望。