Kim Jong-Tae, Youn Dong Hyuk, Kim Bong Jun, Rhim Jong Kook, Jeon Jin Pyeong
Institute of New Frontier Research, Hallym University College of Medicine, Chuncheon, Korea.
Department of Neurosurgery, Jeju National University College of Medicine, Jeju, Korea.
J Korean Neurosurg Soc. 2022 Mar;65(2):161-172. doi: 10.3340/jkns.2021.0126. Epub 2022 Feb 24.
Although technological advances and clinical studies on stem cells have been increasingly reported in stroke, research targeting hemorrhagic stroke is still lacking compared to that targeting ischemic stroke. Studies on hemorrhagic stroke are also being conducted, mainly in the USA and China. However, little research has been conducted in Korea. In reality, stem cell research or treatment is unfamiliar to many domestic neurosurgeons. Nevertheless, given the increased interest in regenerative medicine and the increase of life expectancy, attention should be paid to this topic. In this paper, we summarized pre-clinical rodent studies and clinical trials using stem cells for hemorrhagic stroke. In addition, we discussed results of domestic investigations and future perspectives on stem cell research for a better understanding.
尽管在中风领域,关于干细胞的技术进步和临床研究报道日益增多,但与缺血性中风的研究相比,针对出血性中风的研究仍然不足。针对出血性中风的研究也在进行,主要集中在美国和中国。然而,韩国在此方面的研究较少。实际上,许多国内神经外科医生对干细胞研究或治疗并不熟悉。尽管如此,鉴于对再生医学的兴趣增加以及预期寿命的延长,应关注这一主题。在本文中,我们总结了使用干细胞治疗出血性中风的临床前啮齿动物研究和临床试验。此外,我们还讨论了国内的研究结果以及干细胞研究的未来前景,以便更好地理解。