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中国衣原体流产感染引起的血流感染和肺炎:一例报告。

Bloodstream infection and pneumonia caused by Chlamydia abortus infection in China: a case report.

机构信息

Department of Respiratory Medicine, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210000, China.

出版信息

BMC Infect Dis. 2022 Feb 23;22(1):181. doi: 10.1186/s12879-022-07158-z.

Abstract

BACKGROUND

Chlamydia abortus is generally considered to cause abortion, stillbirth, and gestational sepsis in pregnant women, but it's rare in bloodstream infection and pneumonia.

CASE PRESENTATION

We present details of a patient with bloodstream infection and pneumonia caused by Chlamydia abortus. Both blood next-generation sequencing (NGS) and sputum NGS indicate Chlamydia abortus infection. The patient received intravenous infusion of piperacillin sodium and tazobactam sodium (4.5 g/8 h) and moxifloxacin (0.4 g/d) and oral oseltamivir (75 mg/day). Within one month of follow-up, the patient's clinical symptoms were significantly improved, and all laboratory parameters showed no marked abnormality. However, chest computer tomography (CT) showed the inflammation wasn't completely absorbed. And we are still following up.

CONCLUSIONS

Chlamydia abortus can cause pneumonia in humans. NGS has the particular advantage of quickly and accurately identifying the infection of such rare pathogens. Pneumonia is generally not life-threatening, and has a good prognosis with appropriate treatment. However, Chlamydia infection can lead to serious visceral complications which clinicians should pay attention to.

摘要

背景

沙眼衣原体通常被认为会导致孕妇流产、死产和妊娠败血症,但很少引起血流感染和肺炎。

病例介绍

我们介绍了一位由沙眼衣原体引起血流感染和肺炎的患者的详细情况。血液和痰液的下一代测序(NGS)均提示沙眼衣原体感染。患者接受了注射用哌拉西林钠他唑巴坦钠(4.5g/8h)和莫西沙星(0.4g/d)以及口服奥司他韦(75mg/天)治疗。在一个月的随访期间,患者的临床症状明显改善,所有实验室参数均未见明显异常。然而,胸部计算机断层扫描(CT)显示炎症尚未完全吸收。我们仍在继续随访。

结论

沙眼衣原体可引起人类肺炎。NGS 具有快速准确识别此类罕见病原体感染的独特优势。肺炎一般不会危及生命,且经适当治疗预后良好。但是,沙眼衣原体感染可导致严重内脏并发症,临床医生应予以重视。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa14/8867867/da0abb4b48f1/12879_2022_7158_Fig1_HTML.jpg

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