Department of Physics, Emory University, Atlanta, Georgia, United States of America.
Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America.
PLoS Comput Biol. 2022 Feb 24;18(2):e1009867. doi: 10.1371/journal.pcbi.1009867. eCollection 2022 Feb.
Aging affects almost all aspects of an organism-its morphology, its physiology, its behavior. Isolating which biological mechanisms are regulating these changes, however, has proven difficult, potentially due to our inability to characterize the full repertoire of an animal's behavior across the lifespan. Using data from fruit flies (D. melanogaster) we measure the full repertoire of behaviors as a function of age. We observe a sexually dimorphic pattern of changes in the behavioral repertoire during aging. Although the stereotypy of the behaviors and the complexity of the repertoire overall remains relatively unchanged, we find evidence that the observed alterations in behavior can be explained by changing the fly's overall energy budget, suggesting potential connections between metabolism, aging, and behavior.
衰老几乎影响生物体的所有方面——其形态、生理机能和行为。然而，要分离出调节这些变化的生物机制却很困难，这可能是由于我们无法在整个生命周期内描述动物的全部行为范围。我们使用果蝇（D. melanogaster）的数据来衡量行为范围随年龄的变化。我们观察到在衰老过程中行为范围的性别二态性变化模式。尽管行为的刻板性和行为范围的复杂性相对不变，但我们发现有证据表明，行为的观察到的变化可以通过改变苍蝇的整体能量预算来解释，这表明新陈代谢、衰老和行为之间存在潜在联系。
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