Department of Materials Engineering, Ming Chi University of Technology, New Taipei City, 243303, Taiwan.
Sci Rep. 2022 Mar 3;12(1):3557. doi: 10.1038/s41598-022-07338-6.
Better sensitivity of a biosensor could boost up the detection limit of analytes, thus a must in the fields of bio-sensing and bio-detection. To further enhance the sensitivity of a biosensor, in this work, we design an oblique-flat-sheet metamaterial perfect absorber (MPA) to concentrate the hot spots within air between the oblique flat sheet and the continuous ground metal, thus enabling fully interaction between analytes and hot spots. The corresponding field distributions in simulation corroborated our assumption and its sensitivity could be up to 1049 nm/RIU. Then, we fabricated the sample by e-beam lithography process for a seed layer and simply tilting the sample during deposition to obtain oblique flat sheets. When considering the stochastic nature of the deposited multiple oblique flat sheets, we modified the metallic upper resonator of the MPA from the single oblique-flat-sheet into randomly distributed oblique-wire-bundle (OWB) and in simulation, its sensitivity is boosted up to 3319 nm/RIU. In experiments, the measured sensitivity is 1329 nm/RIU under different concentrations of glucose solutions that is four times larger than the 330 nm/RIU of the planar MPA. The higher sensitivity was attributed to that the OWB MPA could provide hot spots within air not only between OWB and grounded metal but also among wires. Moreover, the OWB could also trap and concentrate the analytes locally.
生物传感器的灵敏度越高,可以提高分析物的检测极限,因此在生物传感和生物检测领域非常重要。为了进一步提高生物传感器的灵敏度,在这项工作中,我们设计了一种倾斜平板超材料完美吸收器(MPA),将空气内部的热点集中在倾斜平板和连续金属之间,从而实现分析物和热点之间的充分相互作用。模拟中的相应场分布证实了我们的假设,其灵敏度可高达 1049nm/RIU。然后,我们通过电子束光刻工艺制造了样品的种子层,并在沉积过程中简单地倾斜样品以获得倾斜平板。考虑到沉积的多个倾斜平板的随机性,我们将 MPA 的金属上谐振器从单个倾斜平板修改为随机分布的倾斜线束(OWB),在模拟中,其灵敏度提高到 3319nm/RIU。在实验中,在不同浓度的葡萄糖溶液下,测量得到的灵敏度为 1329nm/RIU,比平面 MPA 的 330nm/RIU 大 4 倍。更高的灵敏度归因于 OWB MPA 不仅可以在 OWB 和接地金属之间,而且可以在电线之间提供空气内部的热点。此外,OWB 还可以将分析物局部捕获和集中。