Kadkhoda Sepideh, Ghafouri-Fard Soudeh
Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cancer Cell Int. 2022 Mar 5;22(1):105. doi: 10.1186/s12935-022-02531-z.
miR-630 is encoded by MIR630 gene (NC_000015.10) on 15q24.1. This miRNA is mostly associated with cytokine signaling in immune system. Several neoplastic as well as non-neoplastic conditions have been linked with dysregulation of miR-630. It is an oncogenic miRNA in renal cell carcinoma, multiple myeloma, colorectal cancer, acute lymphoblastic leukemia, ovarian cancer and prostate cancer. On the other hand, it is a putative tumor suppressor miRNA in lung, cervical, breast, thyroid and esophageal tissues. In a number of other tissues, data regarding the role of miR-630 in the carcinogenesis is conflicting. Expression levels of miR-630 can be used as markers for prediction of cancer course. Moreover, miR-630 can influence response to chemoradiotherapy. This miRNA is also involved in the pathoetiology of IgA nephropathy, obstructive sleep apnea, age-related nuclear cataract and vitiligo. In the present review, we discuss the role of miR-630 in these conditions.
miR - 630由位于15q24.1的MIR630基因（NC_000015.10）编码。这种微小RNA主要与免疫系统中的细胞因子信号传导相关。几种肿瘤性以及非肿瘤性疾病都与miR - 630的失调有关。在肾细胞癌、多发性骨髓瘤、结直肠癌、急性淋巴细胞白血病、卵巢癌和前列腺癌中，它是一种致癌性微小RNA。另一方面，在肺、宫颈、乳腺、甲状腺和食管组织中，它是一种假定的肿瘤抑制性微小RNA。在许多其他组织中，关于miR - 630在致癌过程中作用的数据存在矛盾。miR - 630的表达水平可作为预测癌症病程的标志物。此外，miR - 630可影响对放化疗的反应。这种微小RNA还参与了IgA肾病、阻塞性睡眠呼吸暂停、年龄相关性核性白内障和白癜风的发病机制。在本综述中，我们讨论了miR - 630在这些疾病中的作用。
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