视网膜微血管密度与帕金森病的临床进展相关。
Retinal Microvascular Density Was Associated With the Clinical Progression of Parkinson's Disease.
作者信息
Xu Bei, Wang Xin, Guo Jifeng, Xu Huizhuo, Tang Beisha, Jiao Bin, Shen Lu
机构信息
Eye Center of Xiangya Hospital, Central South University, Changsha, China.
Hunan Key Laboratory of Ophthalmology, Changsha, China.
出版信息
Front Aging Neurosci. 2022 Feb 17;14:818597. doi: 10.3389/fnagi.2022.818597. eCollection 2022.
BACKGROUND
Retinal microvascular density has been studied in neurodegenerative diseases, whereas patients with Parkinson's disease (PD) at different clinical stages have been rarely investigated. The present study aimed to evaluate the microvascular variations in superficial retinal capillary plexus (SCP) in patients with PD on different Hoehn-Yahr (H-Y) stages by optical coherence tomography angiography (OCTA), as well as determine their relationships with clinical parameters.
METHODS
In total, 115 patients with PD and 67 healthy controls (HCs) were recruited. The PD group was divided into three groups based on the H-Y stage. The OCTA examination was performed in all participants, and the macular vessel density (m-VD), peripapillary vessel density (p-VD), and foveal avascular zone (FAZ) area were measured.
RESULTS
The m-VD in all regions, p-VD in center [6.1 (4.8, 6.95) mm in healthy eyes vs. 5.1 (3.7, 6.4) mm in patients], nasal inner (NI) [18.5 (17.8, 19.3) mm in healthy eyes vs. 17.9 (17.1, 18.7) mm in patients], temporal outer (TO) [19.6 (18.9, 20.2) mm in healthy eyes vs. 19.3 (18.5, 19.7) mm in patients] regions and FAZ area [0.36 (0.32, 0.39) mm in healthy eyes vs. 0.29 (0.26, 0.33) mm in patients] noticeably decreased in PD groups compared with HC ( < 0.05). Moreover, the FAZ area was suggested to decline significantly in patients with PD with H-Y I stage ( < 0.05), while it was more serious in the H-Y III stage in patients. Furthermore, we found that m-VD exhibited a significant negative correlation with age, disease duration, UPDRS scores, NMSS scores, and H-Y stage.
CONCLUSION
OCTA has the potential to non-invasively detect the microvascular changes in patients with PD with different clinical stages , and it may be a valuable tool to monitor the PD progression.
背景
视网膜微血管密度已在神经退行性疾病中得到研究，而处于不同临床阶段的帕金森病（PD）患者则很少被研究。本研究旨在通过光学相干断层扫描血管造影（OCTA）评估不同 Hoehn-Yahr（H-Y）分期的 PD 患者浅表视网膜毛细血管丛（SCP）中的微血管变化，并确定它们与临床参数的关系。
方法
共招募了 115 例 PD 患者和 67 名健康对照者（HCs）。PD 组根据 H-Y 分期分为三组。对所有参与者进行 OCTA 检查，并测量黄斑血管密度（m-VD）、视乳头周围血管密度（p-VD）和中心凹无血管区（FAZ）面积。
结果
与 HC 相比，PD 组所有区域的 m-VD、中心区的 p-VD[健康眼为 6.1（4.8，6.95）mm，患者为 5.1（3.7，6.4）mm]、鼻内侧（NI）[健康眼为 18.5（17.8，19.3）mm，患者为 17.9（17.1，18.7）mm]、颞外侧（TO）[健康眼为 19.6（18.9，20.2）mm，患者为 19.3（18.5，19.7）mm]区域以及 FAZ 面积[健康眼为 0.36（0.32，0.39）mm，患者为 0.29（0.26，0.33）mm]均显著降低（P<0.05）。此外，H-Y I 期的 PD 患者 FAZ 面积显著下降（P<0.05），而在 H-Y III 期患者中更为严重。此外，我们发现 m-VD 与年龄、病程、UPDRS 评分、NMSS 评分和 H-Y 分期呈显著负相关。
结论
OCTA 有潜力无创检测不同临床阶段 PD 患者的微血管变化，它可能是监测 PD 进展的有价值工具。
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