Department of Pulmonary, School of Medicine, Cukurova University, Adana, Turkey.
Department of Translational Medicine, Graduate School of Health Sciences, Cukurova University, Adana, Turkey.
J Dev Orig Health Dis. 2022 Dec;13(6):674-682. doi: 10.1017/S2040174422000083. Epub 2022 Mar 8.
There is an accumulating data that shows relation between childhood adversity and vulnerability to chronic diseases as well as epigenetic influences that in turn give rise to these diseases. Asthma is one of the chronic diseases that is influenced from genetic regulation of the inflammatory biomolecules and therefore the hypothesis in this research was childhood adversity might have caused epigenetic differentiation in the asthma-related genes in the population who had childhood trauma. To test this hypothesis, the literature was systematically reviewed to extract epigenetically modified gene data of the adults who had childhood adversity, and affected genes were further evaluated for their association with asthma. PRISMA guidelines were adopted and PubMed and Google Scholar were included in the searched databases, to evaluate epigenetic modifications in asthma-related genes of physically, emotionally or sexually abused children. After retrieving a total of 5245 articles, 36 of them were included in the study. Several genes and pathways that may contribute to pathogenesis of asthma development, increased inflammation, or response to asthma treatment were found epigenetically affected by childhood traumas. Childhood adversity, causing epigenetic changes in DNA, may lead to asthma development or influence the course of the disease and therefore should be taken into account for the prolonged health consequences.
越来越多的数据表明，儿童期逆境与易患慢性疾病之间存在关联，以及表观遗传的影响，进而导致这些疾病的发生。哮喘是受炎症生物分子的遗传调控影响的慢性疾病之一，因此本研究的假设是，儿童期逆境可能导致有儿童创伤的人群中与哮喘相关的基因发生表观遗传分化。为了验证这一假设，系统地回顾了文献，以提取有儿童期逆境的成年人中受表观遗传修饰的基因数据，并进一步评估了这些受影响的基因与哮喘的关联。采用 PRISMA 指南，检索了 PubMed 和 Google Scholar 数据库，以评估身体、情感或性虐待儿童的哮喘相关基因的表观遗传修饰。总共检索到 5245 篇文章，其中 36 篇被纳入研究。研究发现，一些可能导致哮喘发病机制、炎症增加或对哮喘治疗反应的基因和途径，受儿童创伤的表观遗传影响。儿童期逆境导致 DNA 的表观遗传改变，可能导致哮喘的发生或影响疾病的进程，因此应该考虑到长期的健康后果。
