氮丙啶的直接三氟甲硫基化反应：阳离子控制下三氟甲硫基化异硫氰酸酯和胺的多样化合成
Direct Trifluoromethylthiolation of Aziridines: Cation-Controlled Diverse Synthesis of Trifluoromethylthiolated Isothiocyanates and Amines.
作者信息
Xin Jingrui, Chen Tengying, Tang Pingping
机构信息
State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.
Haihe Laboratory of Sustainable Chemical Transformations, Tianjin 300192, China.
出版信息
Org Lett. 2022 Mar 18;24(10):2035-2039. doi: 10.1021/acs.orglett.2c00558. Epub 2022 Mar 9.
The direct trifluoromethylthiolation of aziridines with AgSCF and iodides is reported. The β-trifluoromethylthiolated isothiocyanates and amines were selectively obtained by the changed cation of iodide. This strategy is tolerant to a wide range of functional groups with good yields and regioselectivities. In addition, the isothiocyanates can be used for further synthetic manipulation, which offered a convenient approach for SCF-containing compounds.
报道了氮丙啶与AgSCF和碘化物的直接三氟甲硫基化反应。通过改变碘化物的阳离子可选择性地得到β-三氟甲硫基异硫氰酸酯和胺。该策略对多种官能团具有耐受性，产率和区域选择性良好。此外，异硫氰酸酯可用于进一步的合成操作，为含SCF的化合物提供了一种便捷的方法。
Zotero 插件