结直肠癌的诊断和治疗生物标志物：综述
Diagnostic and therapeutic biomarkers in colorectal cancer: a review.
作者信息
de Assis Jéssica Vieira, Coutinho Lucélia Antunes, Oyeyemi Ifeoluwa Temitayo, Oyeyemi Oyetunde Timothy, Grenfell Rafaella Fortini E Queiroz
机构信息
Diagnosis and Therapy of Infectious Diseases and Cancer, René Rachou Institute, Oswaldo Cruz Foundation (Fiocruz) Belo Horizonte, Minas Gerais, Brazil.
Department of Biological Sciences, University of Medical Sciences Ondo, Ondo State, Nigeria.
出版信息
Am J Cancer Res. 2022 Feb 15;12(2):661-680. eCollection 2022.
Colorectal cancer (CRC) is a public health concern and the second most common type of cancer among men and women causing a significant mortality. Biomarkers closely linked to the disease morbidity could holds potential as diagnostic and/or prognostic biomarker for the disease. This review provides an overview of recent advances in the search for colorectal cancer biomarkers through genomics and proteomics according to clinical function and application. Specifically, a number of biomarkers were identified and discussed. Emphasis was placed on their clinical applications relative to the diagnosis and prognosis of CRC. The discovery of more sensitive and specific markers for CRC is an urgent need, and the study of molecular targets is extremely important in this process, as they will allow for a better understanding of colorectal carcinogenesis, identification and validation of potential genetic signatures.
结直肠癌（CRC）是一个公共卫生问题，是男性和女性中第二常见的癌症类型，导致相当高的死亡率。与疾病发病率密切相关的生物标志物有可能成为该疾病的诊断和/或预后生物标志物。本综述根据临床功能和应用，概述了通过基因组学和蛋白质组学寻找结直肠癌生物标志物的最新进展。具体而言，鉴定并讨论了一些生物标志物。重点阐述了它们在结直肠癌诊断和预后方面的临床应用。迫切需要发现更敏感和特异的结直肠癌标志物，在此过程中分子靶点的研究极其重要，因为它们将有助于更好地理解结直肠癌的发生机制，识别和验证潜在的基因特征。
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