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睡眠与眼部疾病:综述。

Sleep and eye disease: A review.

机构信息

Centre for Ophthalmology and Visual Science (incorporating the Lions Eye Institute), University of Western Australia, Perth, Western Australia, Australia.

Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia.

出版信息

Clin Exp Ophthalmol. 2022 Apr;50(3):334-344. doi: 10.1111/ceo.14071. Epub 2022 Mar 16.

Abstract

There is a growing body of literature on the effects of sleep disorders, in particular obstructive sleep apnoea (OSA), on ocular health, with consistent evidence of an increased risk of floppy eyelid syndrome, non-arteritic anterior ischaemic optic neuropathy, diabetic macular oedema, and other retinal vasculature changes in individuals with OSA. However, reports on OSA's associations with glaucoma, papilloedema, diabetic retinopathy, central serous chorioretinopathy, and keratoconus have been conflicting, while links between OSA and age-related macular degeneration have only been described fairly recently. Despite numerous suggestions that OSA treatment may reduce risk of these eye diseases, well-designed studies to support these claims are lacking. In particular, the ocular hypertensive effects of continuous positive airway pressure (CPAP) therapy for OSA requires further investigation into its potential impact on glaucoma risk and management. Reports of ocular surface complications secondary to leaking CPAP masks highlights the importance of ensuring good mask fit. Poor sleep habits have also been linked with increased myopia risk; however, the evidence on this association remains weak.

摘要

关于睡眠障碍(特别是阻塞性睡眠呼吸暂停,OSA)对眼部健康的影响,已经有越来越多的文献报道,一致证据表明 OSA 患者患眼睑松弛综合征、非动脉炎性前部缺血性视神经病变、糖尿病性黄斑水肿和其他视网膜血管变化的风险增加。然而,关于 OSA 与青光眼、视乳头水肿、糖尿病性视网膜病变、中心性浆液性脉络膜视网膜病变和圆锥角膜的相关性的报告一直存在争议,而 OSA 与年龄相关性黄斑变性之间的联系直到最近才被描述。尽管有许多研究表明 OSA 治疗可能降低这些眼部疾病的风险,但缺乏支持这些说法的精心设计的研究。特别是,OSA 持续气道正压通气(CPAP)治疗的眼高压作用需要进一步研究其对青光眼风险和管理的潜在影响。CPAP 面罩泄漏导致的眼表面并发症的报告突出表明确保良好的面罩适配的重要性。不良的睡眠习惯也与近视风险增加有关;然而,关于这种相关性的证据仍然很薄弱。

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