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严重急性呼吸综合征冠状病毒2型免疫复合物致敏会引发药物超敏反应伴嗜酸性粒细胞增多和系统症状(DRESS)综合征吗?

Does sensitization by SARS-CoV-2 immune complexes trigger DRESS syndrome?

作者信息

Cruz Virgínia Barbeitos, Júnior Luiz Fernando Fróes Fleury, Kobal Christiane Reis, da Silva Nilzio Antonio

机构信息

Health Sciences Program, School of Medicine, Universidade Federal de Goiás, Goiânia, GO, Brazil.

Clinical Hospital, School of Medicine, Universidade Federal de Goiás, Goiânia, GO, Brazil.

出版信息

Braz J Infect Dis. 2022 Mar-Apr;26(2):102337. doi: 10.1016/j.bjid.2022.102337. Epub 2022 Feb 28.

Abstract

The diagnosis of coronavirus disease (COVID-19) has been a great challenge since the infection affects not only the respiratory system, but also different organs, given the intense inflammatory and autoimmune reaction triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Herein we present a case of a 36-year-old male patient, with some comorbidities and previous use of carbamazepine, who developed a severe condition triggered by COVID-19, including extensive exfoliative erythroderma and severe impairment of liver function, which lasted approximately 80 days.

摘要

由于严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引发强烈的炎症和自身免疫反应,冠状病毒病(COVID-19)的感染不仅会影响呼吸系统,还会累及不同器官,因此其诊断一直是一项巨大挑战。在此,我们报告一例36岁男性患者,该患者有一些合并症且曾使用过卡马西平,其因COVID-19引发了严重病症,包括广泛的剥脱性红皮病和严重的肝功能损害,病程持续了约80天。

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