Department of Physical Therapy, Clarkson University, Potsdam, NY 13699, USA.
Department of Biology, Clarkson University, Potsdam, NY 13699, USA.
Nutrients. 2022 Jan 21;14(3):466. doi: 10.3390/nu14030466.
Recent scientific evidence suggests that traits energy and fatigue are two unique unipolar moods with distinct mental and physical components. This exploratory study investigated the correlation between mental energy (ME), mental fatigue (MF), physical energy (PE), physical fatigue (PF), and the gut microbiome. The four moods were assessed by survey, and the gut microbiome and metabolome were determined from 16 S rRNA analysis and untargeted metabolomics analysis, respectively. Twenty subjects who were 31 ± 5 y, physically active, and not obese (26.4 ± 4.4 kg/m2) participated. Bacteroidetes (45%), the most prominent phyla, was only negatively correlated with PF. The second most predominant and butyrate-producing phyla, Firmicutes (43%), had members that correlated with each trait. However, the bacteria Anaerostipes was positively correlated with ME (0.048, p = 0.032) and negatively with MF (−0.532, p = 0.016) and PF (−0.448, p = 0.048), respectively. Diet influences the gut microbiota composition, and only one food group, processed meat, was correlated with the four moods—positively with MF (0.538, p = 0.014) and PF (0.513, p = 0.021) and negatively with ME (−0.790, p < 0.001) and PE (−0.478, p = 0.021). Only the Firmicutes genus Holdemania was correlated with processed meat (r = 0.488, p = 0.029). Distinct metabolic profiles were observed, yet these profiles were not significantly correlated with the traits. Study findings suggest that energy and fatigue are unique traits that could be defined by distinct bacterial communities not driven by diet. Larger studies are needed to confirm these exploratory findings.
最近的科学证据表明，精力和疲劳是两种独特的单极情绪，具有不同的心理和生理成分。这项探索性研究调查了心理能量 (ME)、心理疲劳 (MF)、身体能量 (PE)、身体疲劳 (PF) 和肠道微生物组之间的相关性。通过问卷调查评估了这四种情绪，通过 16S rRNA 分析和非靶向代谢组学分析分别确定了肠道微生物组和代谢组。20 名年龄在 31 ± 5 岁、身体活跃且不肥胖（26.4 ± 4.4 kg/m2）的受试者参与了研究。厚壁菌门（45%）是最显著的门，仅与 PF 呈负相关。第二大且主要产生丁酸盐的门，Firmicutes（43%），其成员与每个特征相关。然而，拟杆菌属 Anaerostipes 与 ME 呈正相关（0.048，p = 0.032），与 MF（-0.532，p = 0.016）和 PF（-0.448，p = 0.048）呈负相关。饮食会影响肠道微生物群的组成，只有一种食物组，即加工肉，与四种情绪相关——与 MF（0.538，p = 0.014）和 PF（0.513，p = 0.021）呈正相关，与 ME（-0.790，p < 0.001）和 PE（-0.478，p = 0.021）呈负相关。只有 Firmicutes 属的 Holdemania 与加工肉呈正相关（r = 0.488，p = 0.029）。观察到了不同的代谢谱，但这些谱与特征没有显著相关性。研究结果表明，精力和疲劳是两种独特的特征，可以由不同的细菌群落定义，而不是由饮食驱动。需要更大规模的研究来证实这些探索性发现。
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