光药理学控制光可切换脂质的细胞信号转导。
Photopharmacological control of cell signaling with photoswitchable lipids.
机构信息
Department of Chemistry, New York University, 100 Washington Square East, New York, NY, 10003-6699, USA.
Department of Chemistry, New York University, 100 Washington Square East, New York, NY, 10003-6699, USA.
出版信息
Curr Opin Pharmacol. 2022 Apr;63:102202. doi: 10.1016/j.coph.2022.102202. Epub 2022 Mar 9.
Many aspects of cell signaling are controlled by lipids. Several signaling lipids have been functionalized with an azobenzene photoswitch to control underlying signaling dynamics with light. Herein, we provide an overview of signaling photolipids developed to date focusing on their biological applications. These include immunomodulation, kinase translocation, apoptosis, ion channel activation, G-protein coupled receptor activation, and neurogenesis.
细胞信号转导的许多方面受脂质控制。几种信号脂质已被用光响应的偶氮苯光开关功能化，以用光控制潜在的信号转导动力学。在此，我们提供了迄今为止开发的信号转导光脂的概述，重点介绍它们的生物学应用。这些应用包括免疫调节、激酶易位、细胞凋亡、离子通道激活、G 蛋白偶联受体激活和神经发生。
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