针对强直性脊柱炎中疾病相关决定簇的细胞毒性T淋巴细胞。
Cytotoxic T lymphocytes against disease-associated determinant(s) in ankylosing spondylitis.
作者信息
Geczy A F, McGuigan L E, Sullivan J S, Edmonds J P
出版信息
J Exp Med. 1986 Sep 1;164(3):932-7. doi: 10.1084/jem.164.3.932.
Abstract
Cytotoxic T lymphocytes, induced by stimulating the PBMC of an HLA-B27+ normal individual (B27+, AS-) with the PBMC of an HLA-identical sibling suffering from ankylosing spondylitis (AS) (B27+, AS+), specifically lyse B27+, AS+ PBMC but not PBMC from HLA-27+ or B27-, AS- normal controls, or from HLA-B27- AS patients (B27-,AS+). CTL of similar specificity can also be raised by immunizing in vitro B27+,AS- cells with autologous cells modified by cross-reactive bacterial antigens. These results suggest that CTL can recognize certain bacterial antigens in association with HLA-B27 and that this interaction may lead to an inflammatory episode during the initial stages of the disease.
摘要
通过用患强直性脊柱炎（AS）的 HLA 相同同胞（B27 +，AS +）的外周血单个核细胞（PBMC）刺激 HLA - B27 + 正常个体（B27 +，AS -）的 PBMC 诱导产生的细胞毒性 T 淋巴细胞，能特异性裂解 B27 +，AS + 的 PBMC，但不能裂解来自 HLA - 27 + 或 B27 -、AS - 正常对照个体，或来自 HLA - B27 - AS 患者（B27 -，AS +）的 PBMC。通过用经交叉反应性细菌抗原修饰的自体细胞在体外免疫 B27 +，AS - 细胞，也可产生具有类似特异性的细胞毒性 T 淋巴细胞。这些结果表明，细胞毒性 T 淋巴细胞能够识别与 HLA - B27 相关的某些细菌抗原，并且这种相互作用可能在疾病的初始阶段引发炎症反应。
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