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评估生物相容琼脂负载的 ZnS/CuFeO 磁性纳米管的催化和抗菌活性。

Assessment of catalytic and antibacterial activity of biocompatible agar supported ZnS/CuFeO magnetic nanotubes.

机构信息

Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran.

出版信息

Sci Rep. 2022 Mar 16;12(1):4503. doi: 10.1038/s41598-022-08318-6.

Abstract

The tubular magnetic agar supported ZnS/CuFeO nanocomposite was fabricated via a simple procedure. Next, various properties of this nanocomposite were studied by employing multiple characterization techniques including FT-IR, EDX, SEM, TEM,VSM, XRD, and TGA. Then, the catalytic and antibacterial applications were evaluated for the fabricated nanocomposite. Based on the experimental result, the nanocomposite showed excellent catalytic activity to promote the multicomponent reaction between ethyl acetoacetate, hydrazine hydrate, aromatic aldehydes, and malononitrile to synthesize a variety of dihydropyrano[2,3-c]pyrazole derivatives with high yields (89-95%) in acceptable reaction times (20-40 min) under mild reaction conditions. It can be efficiently recycled and re-work in six consequent runs without notable reduction in catalytic productiveness. Furthermore, its antibacterial activity was assessed against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) bacteria by the agar diffusion and plate-count methods. These results indicate that the width of the inhibition zone around the S. aureus (G bacterium) is more than that of E. coli (G bacterium). Moreover, the agar supported ZnS/CuFeO nanocomposite exhibited strong prevention of the bacterial colonies' growth.

摘要

管状磁性琼脂负载的 ZnS/CuFeO 纳米复合材料是通过一种简单的方法制备的。接下来,通过多种表征技术,包括 FT-IR、EDX、SEM、TEM、VSM、XRD 和 TGA,研究了该纳米复合材料的各种性质。然后,评估了所制备的纳米复合材料的催化和抗菌应用。根据实验结果,纳米复合材料表现出优异的催化活性,能够促进乙基乙酰乙酸酯、水合肼、芳醛和丙二腈之间的多组分反应,以高收率(89-95%)在可接受的反应时间(20-40 分钟)下温和的反应条件下合成各种二氢吡喃并[2,3-c]吡唑衍生物。它可以在六次连续运行中有效回收和再利用,而催化产物的产率没有明显降低。此外,通过琼脂扩散和平板计数法评估了其对金黄色葡萄球菌(S. aureus)和大肠杆菌(E. coli)细菌的抗菌活性。这些结果表明,金黄色葡萄球菌(G 细菌)周围抑制区的宽度大于大肠杆菌(G 细菌)。此外,琼脂负载的 ZnS/CuFeO 纳米复合材料表现出强烈的抑制细菌菌落生长的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b02/8927411/ff6b9006e122/41598_2022_8318_Fig1_HTML.jpg

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