Interspecies Regulation Between and Colonized on Healed Skin After Injury.

spp. colonize commensally on the human skin. Some commensal coagulase-negative staphylococci and are also involved in nosocomial infections. Bacteria were collected from skin healed from pressure injury (PI). After the collection time points, some patients suffered from recurrent PI (RPI). This study analyzed the characteristics of spp. on healed skin before recurrence between healed skin that suffered from RPI within 6 weeks (RPI group) and healed skin that did not suffer within the duration (non-RPI group) by spp.-specific sequencing. Of the seven patients in the RPI group, two were dominated by and four by , coagulase-negative human commensal staphylococci in the RPI group. Using mouse models, both and , but not , colonized on skin healed from injury at significantly higher rates than normal skin. Although subcutaneous injection of did not induce lesion formation, the bacterium exhibited high hemolytic activity on human red blood cells. Lesion formation by subcutaneous injection of was significantly suppressed in the presence of . The hemolytic activity of rabbit blood cells of was suppressed by , whereas the hemolytic activity of was dramatically suppressed by . Data indicated that each of the two spp. suppresses the pathogenicity of the other and that the imbalance between the two is associated with RPI.