The Second Affiliated Hospital of North Sichuan Medical College, Sichuan Mianyang 404 Hospital, Mianyang, China.
Dalian Medical University, Dalian Medical University Graduate School, Dalian, China.
Diagn Cytopathol. 2022 Jun;50(6):300-312. doi: 10.1002/dc.24954. Epub 2022 Mar 24.
To compare and analyze the diagnostic efficacy of nuclear matrix protein 22 (NMP22) and urine cytology (UC) in the diagnosis of bladder cancer.
Search the Chinese and English studies on NMP22 and urinary cytology in the diagnosis of bladder tumors published between 1999 and June, and conduct quality evaluation, data extraction and analysis.
A total of 397 related articles were retrieved, and 12 articles were finally included after screening, including 2456 subjects. The heterogeneity test shows that there is no discernible threshold effect. Perform meta-analysis according to the random effects model. The results showed that the total sensitivity of NMP22 and UC were 0.79 (95% CI [0.73, 0.84]) (CI: Confidence interval), 0.55 (95% CI [0.41, 0.69]), and the total specificity 0.59 (95% CI [0.46], respectively, 0.71), 0.91 (95% CI (0.81, 0.96]), +LR 1.9 (95% CI [1.4, 2.6]) (+LR: positive likelihood ration), 5.9 (95% CI [3.3, 10.6]), -LR 0.35 (-LR: negative likelihood ration), respectively (95% CI [0.27, 0.47]), 0.49 (95% CI [0.38, 0.64]), diagnostic odds ratios 5 (95% CI [3, 9]), 12 (95% CI [7, 21]). The area under the summary receiver operating characteristics curve (AUC) was 0.79 (95% CI [0.75, 0.82]) and 0.81 (95% CI [0.77, 0.84]), respectively.
NMP22 has moderate diagnostic efficiency for bladder cancer. Its sensitivity is greater than UC, but its specificity is significantly lower than that of UC. At present, it cannot replace traditional cystoscopy and UC, but it can be combined to detect bladder tumors. It plays a major role in screening, postoperative monitoring and follow-up.
比较和分析核基质蛋白 22（NMP22）和尿细胞学（UC）在膀胱癌诊断中的诊断效能。
检索 1999 年 1 月至 2023 年 6 月发表的中英文关于 NMP22 和尿细胞学诊断膀胱癌的研究，并进行质量评价、数据提取和分析。
共检索到 397 篇相关文献，筛选后最终纳入 12 篇文献，共 2456 例患者。异质性检验显示无明显阈值效应，采用随机效应模型进行 Meta 分析。结果显示，NMP22 和 UC 的总灵敏度分别为 0.79（95%CI[0.73，0.84]）、0.55（95%CI[0.41，0.69]），总特异度分别为 0.59（95%CI[0.46]，0.71）、0.91（95%CI[0.81，0.96]），+LR 分别为 1.9（95%CI[1.4，2.6]）、5.9（95%CI[3.3，10.6]），-LR 分别为 0.35（95%CI[0.27，0.47]）、0.49（95%CI[0.38，0.64]），诊断比值比分别为 5（95%CI[3，9]）、12（95%CI[7，21]）。汇总受试者工作特征曲线下面积（AUC）分别为 0.79（95%CI[0.75，0.82]）、0.81（95%CI[0.77，0.84]）。
NMP22 对膀胱癌具有中等诊断效能，其灵敏度大于 UC，但特异度明显低于 UC。目前不能替代传统的膀胱镜和 UC，但可联合检测膀胱癌，在筛查、术后监测和随访中发挥重要作用。
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