Institute of Radiology, Department of Medicine, University of Udine, University Hospital S. Maria della Misericordia, p.le S. Maria della Misericordia n. 15, 33100 Udine, Italy.
Department of Biomedical Sciences and Morphological and Functional Imaging, Policlinico Universitario G. Martino, University of Messina, Via Consolare Valeria n. 1, 98100, Messina, Italy.
Eur J Radiol. 2022 May;150:110267. doi: 10.1016/j.ejrad.2022.110267. Epub 2022 Mar 18.
To investigate the inter-reader agreement of the Prostate imaging quality (PI-QUAL) for multiparametric magnetic resonance imaging (mpMRI).
We included 66 men who underwent 1.5 T mpMRI in June 2020-July 2020 in center 1, with no exclusion criteria. mpMRI included multiplanar T2-weighted imaging (T2WI), Diffusion-weighted imaging (DWI), and dynamic contrast-enhanced imaging (DCE). Two readers from center 2 (experience <1000 to >1500 examinations), blinded to clinical history but not to acquisition parameters, independently assessed PI-QUAL qualitative/anatomical items of each mpMRI sequence, final PI-QUAL score (1-5), and the Prostate imaging reporting and data system version 2.1 (PI-RADSv2.1) category of the index lesion. Cohen's kappa statistics (k) or prevalence-adjusted-bias-adjusted kappa (PABAK) were used to calculate the inter-reader agreement in assessing the PI-QUAL (1-to-5 scale and 1-2 versus 3 versus 4-5), the diagnostic quality of each mpMRI sequence, qualitative/anatomical items, and PI-RADSv2.1 category.
The inter-reader agreement for PI-QUAL category was moderate upon 1-5 scale (k = 0.55; 95%CI 0.39-0.71) or 1-3 scale (k = 0.51; 95%CI 0.29-0.72), with 90.9% examinations categorized PI-QUAL ≥ 3 by readers. The agreement in assessing a sequence as diagnostic was higher for T2WI (k = 0.76) than DCE (PABAK = 0.61) and DWI (k = 0.46), ranging moderate-to-substantial for most of the items. Readers provided comparable PI-RADSv2.1 categorization (k = 0.88 [excellent agreement]; 95%CI 0.81-0.96), with most PI-RADSv2.1 ≥ 3 assignments found in PI-QUAL ≥ 3 examinations (43/46 by reader 1, and 47/47 by reader 2).
The reproducibility of PI-QUAL was moderate. Higher PI-QUAL scores were associated with excellent inter-reader agreement for PI-RADSv2.1 categorization.
研究多参数磁共振成像（mpMRI）中前列腺成像质量（PI-QUAL）的读者间一致性。
我们纳入了 66 名于 2020 年 6 月至 7 月在中心 1 接受 1.5T mpMRI 的男性患者，无排除标准。mpMRI 包括多平面 T2 加权成像（T2WI）、弥散加权成像（DWI）和动态对比增强成像（DCE）。来自中心 2 的两位读者（经验<1000 次至>1500 次检查）对每个 mpMRI 序列的 PI-QUAL 定性/解剖项目、最终 PI-QUAL 评分（1-5 分）和前列腺成像报告和数据系统第 2.1 版（PI-RADSv2.1）的指数病变进行独立评估。采用 Cohen kappa 统计量（k）或调整后偏倚的 Cohen kappa（PABAK）评估 PI-QUAL（1-5 分和 1-3 分与 3 分与 4-5 分）、每个 mpMRI 序列、定性/解剖项目和 PI-RADSv2.1 类别的读者间一致性。
PI-QUAL 类别在 1-5 分或 1-3 分时的读者间一致性为中度（k=0.55；95%CI 0.39-0.71），90.9%的检查由读者归类为 PI-QUAL≥3。与 DCE（PABAK=0.61）和 DWI（k=0.46）相比，T2WI 作为诊断序列的评估具有更高的一致性（k=0.76），大多数项目的一致性为中度至高度。读者提供了可比的 PI-RADSv2.1 分类（k=0.88[极好的一致性]；95%CI 0.81-0.96），PI-QUAL≥3 的检查中大多数 PI-RADSv2.1≥3 （读者 1 为 43/46，读者 2 为 47/47）。
PI-QUAL 的可重复性为中度。更高的 PI-QUAL 评分与 PI-RADSv2.1 分类的良好读者间一致性相关。
