比较糖尿病患者和非糖尿病患者白内障超声乳化术后角膜内皮变化。

Comparison of corneal endothelial changes following phacoemulsification in diabetic and non-diabetic patients.

机构信息

Department of Ophthalmology, Vivekananda Polyclinic and Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

出版信息

Indian J Ophthalmol. 2022 Apr;70(4):1208-1213. doi: 10.4103/ijo.IJO_1955_21.

DOI:10.4103/ijo.IJO_1955_21

PMID:35326017

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9240528/

Abstract

PURPOSE

To study corneal endothelial changes post phacoemulsification in diabetic and non-diabetic patients.

METHODS

A comparative, prospective, observational study was conducted on 100 diabetic and 100 non-diabetics who underwent phacoemulsification. All patients were operated by the same surgeon by using the phaco chop technique to exclude any surgeon-related bias. Endothelial cell count, CCT, and coefficient of variance (CV) were measured with a specular microscope along with BCVA preoperatively and at 1 week, 4 weeks, and 3 months postoperatively. For statistical analysis, data were analyzed by using SPSS (version 27.0; SPSS Inc., Chicago, IL, USA). Data were summarized as mean and standard deviation for numerical variables and count and percentages for categorical variables. Chi square test, independent sample T test, and paired T test were used to compare the data. P ≤ 0.05 was considered statistically significant.

RESULTS

: Postoperatively at 1 week, 4-week, and 3 months follow-up intervals, the mean endothelial cell count and coefficient of variance were significantly higher, and the mean percentage of hexagonal cells was significantly lower in non diabetic as compared to the diabetic group. A significant difference in mean central corneal thickness of the two groups was observed at 1-week and 4-weeks postoperative intervals; at both these intervals, the mean value was significantly higher in non diabetic as compared to the non-diabetic group. However, at 3-months post-operative interval, the difference between the two groups was not significant statistically. Mean BCVA values were significantly higher in diabetic as compared to the diabetic group at all three follow-up intervals.

CONCLUSION

: The findings of the present study show that endothelial cell characteristics are adversely affected in diabetic eyes as compared to non-diabetic patients undergoing phacoemulsification; this might also have an effect on the visual outcomes.

摘要

目的

研究超声乳化术后糖尿病患者和非糖尿病患者的角膜内皮变化。

方法

对 100 例糖尿病患者和 100 例非糖尿病患者进行了一项比较、前瞻性、观察性研究，这些患者均接受了超声乳化术。所有患者均由同一位外科医生采用超声乳化劈裂技术进行手术，以排除任何与外科医生相关的偏见。用角膜内皮显微镜测量内皮细胞计数、中央角膜厚度和变异系数（CV），并在术前和术后 1 周、4 周和 3 个月测量最佳矫正视力（BCVA）。采用 SPSS（版本 27.0；SPSS 公司，芝加哥，IL，美国）进行数据分析。数值变量用均数和标准差表示，分类变量用频数和百分比表示。采用卡方检验、独立样本 t 检验和配对 t 检验比较数据。P≤0.05 为统计学意义。

结果

术后 1 周、4 周和 3 个月随访时，非糖尿病组的平均内皮细胞计数和变异系数显著升高，六边形细胞的平均百分比显著降低，与糖尿病组相比。两组在术后 1 周和 4 周时中央角膜厚度的平均值有显著差异；在这两个时间点，非糖尿病组的平均值明显高于非糖尿病组。然而，在术后 3 个月时，两组之间的差异无统计学意义。在所有三个随访时间点，糖尿病组的平均 BCVA 值均显著高于糖尿病组。