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内镜下脊柱手术(BESS和UESS)与显微镜下手术治疗腰椎管狭窄症的系统评价和Meta分析

Endoscopic Spinal Surgery (BESS and UESS) Versus Microscopic Surgery in Lumbar Spinal Stenosis: Systematic Review and Meta-Analysis.

作者信息

Kang Kyu-Bok, Shin Young-Soo, Seo Eun-Min

机构信息

Department of Orthopaedic Surgery, 155087Veterans Health Service Medical Center, Seoul, South Korea.

Department of Orthopedic Surgery, Chunchon Sacred Heart Hospital, 26727Hallym University College of Medicine, Chuncheon, South Korea.

出版信息

Global Spine J. 2022 Oct;12(8):1943-1955. doi: 10.1177/21925682221083271. Epub 2022 Mar 25.

Abstract

STUDY DESIGN

Systematic Review and Meta-Analysis.

OBJECTIVES

Various minimally invasive surgical techniques have been developed as alternatives to conventional surgery. According to recent studies, endoscopic spinal surgery (ESS) (biportal ESS [BESS] or uniportal ESS [UESS]) is more favorable compared with microscopic spinal surgery (MSS). This systematic review and meta-analysis aimed to assess the latest evidence on the use of ESS compared with MSS in lumbar spinal stenosis.

METHODS

A systematic electronic search using PubMed, Embase, Cochrane Central Database, and Korea Med was performed until December 2019 to identify studies that compared ESS and MSS in patients with lumbar spinal stenosis.

RESULTS

Overall, 1167 patients were included from three randomized controlled trials, six retrospective cohorts, and two prospective case-control studies. This review only presented 3 direct comparative studies. The study had inherent limitations specifically in terms of the study design. Meta-analysis of hospital stay (days) showed significant difference between BESS and MSS, UESS and MSS, BESS +UESS, and MSS at the final follow-up (95% confidence interval [CI]: -3.66 to -.77; P = .003; I = 97%, 95% CI: -2.95 to -1.22; P <.00001; I = 90%, and 95% CI: -2.89 to -1.48; P <.00001; I = 96%, respectively). However, meta-analysis showed no significant difference in other results.

CONCLUSIONS

Although a shorter duration of hospital stay was observed in ESS, there were no significant differences in efficacy and safety between ESS and MSS. Further studies are required to validate these results.

摘要

研究设计

系统评价与荟萃分析。

目的

已开发出多种微创手术技术作为传统手术的替代方法。根据最近的研究,与显微镜下脊柱手术(MSS)相比,内镜脊柱手术(ESS)(双孔ESS [BESS]或单孔ESS [UESS])更具优势。本系统评价和荟萃分析旨在评估ESS与MSS用于腰椎管狭窄症的最新证据。

方法

截至2019年12月,使用PubMed、Embase、Cochrane中央数据库和韩国医学数据库进行系统的电子检索,以确定比较ESS和MSS治疗腰椎管狭窄症患者的研究。

结果

总体而言,纳入了来自三项随机对照试验、六项回顾性队列研究和两项前瞻性病例对照研究的1167例患者。本评价仅呈现了3项直接比较研究。该研究存在固有局限性,特别是在研究设计方面。住院时间(天)的荟萃分析显示,在末次随访时,BESS与MSS、UESS与MSS、BESS + UESS与MSS之间存在显著差异(95%置信区间[CI]:-3.66至-0.77;P = 0.003;I² = 97%,95% CI:-2.95至-1.22;P < 0.00001;I² = 90%,以及95% CI:-2.89至-1.48;P < 0.00001;I² = 96%)。然而,荟萃分析显示其他结果无显著差异。

结论

尽管ESS的住院时间较短,但ESS与MSS在疗效和安全性方面无显著差异。需要进一步研究来验证这些结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bac7/9609515/5393b5a288ff/10.1177_21925682221083271-fig1.jpg

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