圆锥角膜不同阶段高阶像差的特征。

Characteristics of Higher-Order Aberrations in Different Stages of Keratoconus.

机构信息

Departments of Innovative Visual Science (S.K., R.I.), and Ophthalmology (S.K., S.M., N.M., K.N.), Osaka University Graduate School of Medicine, Osaka, Japan; SEED Co, Ltd (RI), Tokyo, Japan; Department of Orthoptics (T.M.), Faculty of Medical Technology, Teikyo University, Tokyo, Japan; and Department of Ophthalmology (V.J.), University of Pittsburgh School of Medicine, Pittsburgh, PA.

出版信息

Eye Contact Lens. 2022 Jun 1;48(6):256-260. doi: 10.1097/ICL.0000000000000897. Epub 2022 Mar 14.

DOI:10.1097/ICL.0000000000000897

PMID:35333804

Abstract

OBJECTIVES

To characterize higher-order aberrations (HOAs) in clinical and subclinical keratoconus (KC).

METHODS

The study included 33, 36, and 26 patients with clinical, topographic (no clinical signs), and pretopographic (normal topography and no clinical signs) KC and 30 controls. Ocular and corneal HOAs for the 4-mm pupils were measured using a wavefront sensor and expanded up to the sixth order of Zernike polynomials. The magnitudes of trefoil, coma, tetrafoil, secondary astigmatism, and spherical aberration were calculated via Zernike vector analysis and used as HOA parameters along with total HOAs. Area under the receiver operating characteristic curve (AUROC) values for each wavefront parameter for pretopographic KC were compared.

RESULTS

Control eyes and eyes with pretopographic KC had significantly lower ocular or corneal total HOAs and Zernike vector terms than those with clinical KC and topographic KC, except for ocular tetrafoil between topographic KC and pretopographic KC and spherical aberration among all groups. The AUROCs for corneal total HOAs and corneal coma for pretopographic KC and control eyes were 0.781 (100% sensitivity and 47% specificity) and 0.735 (73% sensitivity and 73% specificity), respectively.

CONCLUSION

Corneal total HOAs and corneal coma exhibited a potential ability to discriminate pretopographic KC from normal control eyes.

摘要

目的

描述临床和亚临床圆锥角膜（KC）的高阶像差（HOA）。

方法

该研究纳入了 33 例、36 例和 26 例临床型、地形图（无临床体征）和前地形图（正常地形图且无临床体征）KC 患者和 30 例对照者。使用波前传感器测量 4mm 瞳孔的眼和角膜 HOA，并扩展到 Zernike 多项式的第六阶。使用 Zernike 矢量分析计算三叶形、彗差、四叶形、二次散光和球差的大小，并将其用作 HOA 参数以及总 HOA。比较前地形图 KC 各波前参数的受试者工作特征曲线（ROC）下面积（AUROC）值。

结果

与临床型 KC 和地形图 KC 相比，对照者眼和前地形图 KC 眼的眼和角膜总 HOA 和 Zernike 矢量项显著较低，除了地形图 KC 和前地形图 KC 之间的眼四叶形和所有组之间的球差。前地形图 KC 和对照者眼的角膜总 HOA 和角膜彗差的 AUROC 分别为 0.781（100%灵敏度和 47%特异性）和 0.735（73%灵敏度和 73%特异性）。