母亲年龄对冻融胚胎移植周期中单胎出生体重的影响。

Impact of Maternal Age on Singleton Birthweight in Frozen Embryo Transfer Cycles.

机构信息

Department of Traditional Chinese Medicine Gynecology, Changhai Hospital, Naval Medical University, Shanghai, China.

Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.

出版信息

Front Endocrinol (Lausanne). 2022 Mar 8;13:830414. doi: 10.3389/fendo.2022.830414. eCollection 2022.

DOI:10.3389/fendo.2022.830414

PMID:35345469

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8957095/

Abstract

BACKGROUND

Previous studies have investigated the effect of maternal age on assisted reproductive technology success rates. However, little is known about the relationship between maternal age and neonatal birthweight in frozen embryo transfer (FET) cycles. Whether maternal age influences singleton birthweight in FET cycles remains to be elucidated.

METHODS

This study was conducted at a tertiary care center, involving singleton live births born to women undergoing frozen-thawed embryo transfer during the period from January 2010 to December 2017. A total of 12,565 women who fulfilled the inclusion criteria were enrolled and grouped into four groups according to the maternal age: <30, 30-34, 35-39, and ≥40 years old. A multivariable linear regression analysis was conducted to reveal the relationship between maternal age and neonatal birthweight with controlling for a number of potential confounders.

RESULTS

The highest proportions of low birthweight (LBW, 4.1%), high birthweight (1.2%), preterm birth (PTB, 5.9%), and very PTB (0.9%) were found in the group over 40 years old, but no significant difference was observed among the four groups. Additionally, the 35-39-year-old group had the highest rate of very LBW (0.6%), whereas the 30-34-year-old group had the lowest rate of small for gestational age (SGA, 2.7%). However, multivariate analyses revealed that neonatal outcomes including PTB, LBW, and SGA were similar between the different maternal age groups.

CONCLUSION

Grouping with different maternal age was not associated with mean birthweight and Z-scores of singletons resulting from FET.

摘要

背景

之前的研究已经调查了母亲年龄对辅助生殖技术成功率的影响。然而，对于冷冻胚胎移植（FET）周期中母亲年龄与新生儿出生体重之间的关系知之甚少。母亲年龄是否影响 FET 周期中的单胎出生体重仍有待阐明。

方法

本研究在一家三级保健中心进行，涉及 2010 年 1 月至 2017 年 12 月期间接受冷冻解冻胚胎移植的女性的单胎活产儿。共有 12565 名符合纳入标准的女性被纳入研究，并根据母亲年龄分为四组：<30 岁、30-34 岁、35-39 岁和≥40 岁。采用多变量线性回归分析来揭示母亲年龄与新生儿出生体重之间的关系，同时控制了一些潜在的混杂因素。

结果

年龄超过 40 岁的组中，低出生体重（LBW，4.1%）、高出生体重（1.2%）、早产（PTB，5.9%）和极早产（0.9%）的比例最高，但四组之间无显著差异。此外，35-39 岁组的极 LBW 发生率最高（0.6%），而 30-34 岁组的 SGA 发生率最低（2.7%）。然而，多变量分析显示，不同年龄组之间的新生儿结局，包括 PTB、LBW 和 SGA，相似。