遗传性综合征相关结直肠癌的管理。

Management of Colorectal Cancer in Hereditary Syndromes.

机构信息

Division of Colorectal Surgery, Department of Surgery, The Ohio State University Medical Center, N737B Doan Hall, 410 West 10th Avenue, Columbus, OH 43210, USA.

Division of Colorectal Surgery, Department of Surgery, The Ohio State University Medical Center, N737B Doan Hall, 410 West 10th Avenue, Columbus, OH 43210, USA; Pediatric and Adult Colorectal Surgery, The Ohio State University Medical Center, Nationwide Children's Hospital, N747 Doan Hall, 410 West 10th Avenue, Columbus, OH 43210, USA.

出版信息

Surg Oncol Clin N Am. 2022 Apr;31(2):307-319. doi: 10.1016/j.soc.2021.11.010. Epub 2022 Mar 9.

DOI:10.1016/j.soc.2021.11.010

PMID:35351280

Abstract

Approximately 5% of all colorectal cancers develop within a hereditary colorectal cancer syndrome. Patients and families with these syndromes have an increased risk of colorectal and extracolonic cancers that develop at an early age. Recognition and diagnosis of these conditions are crucial to management and risk reduction. Surgeons must be aware of the unique aspects of the timing and extent of surgery (both therapeutic and prophylactic) within these syndromes, particularly for the most common syndromes, Lynch syndrome and familial adenomatous polyposis.

摘要

约 5%的结直肠癌发生于遗传性结直肠癌综合征。这些综合征的患者及其家族成员存在结直肠和结直肠外癌症的发病风险增加，且发病年龄较早。识别和诊断这些疾病对于管理和降低风险至关重要。外科医生必须了解这些综合征中手术（包括治疗性和预防性手术）的时机和范围的独特方面，特别是对于最常见的综合征，即林奇综合征和家族性腺瘤性息肉病。