Li Heng, Zhu Yan, Jiang Cong, Wei Jia, Liu Ping, Sun Peipei
School of Chemistry and Materials Science, Jiangsu Provincial Key Laboratory of Material Cycle Processes and Pollution Control, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing Normal University, Nanjing 210023, China.
Org Biomol Chem. 2022 Apr 20;20(16):3365-3374. doi: 10.1039/d2ob00395c.
An efficient HOAc catalyzed three-component reaction of 2-(arylethynyl)anilines with arylaldehydes has been achieved, which leads to the generation of 3,3'-(arylmethylene)bis(1-indoles) with good to excellent yields and high regioselectivity under transition-metal-free conditions. Four new C-C and C-N bonds were effectively formed in a one-pot procedure. Subsequent research on the reaction mechanism indicated that the reaction likely involved the processes of intramolecular cyclization and cascade intermolecular dehydration condensation.
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