Li Yiming, Li Zhenjiang, Feng Jiaxuan, Feng Rui, Zhou Jian, Jing Zaiping
Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, China.
Endovascular Diagnosis and Treatment Center for Aortic Diseases, Department of Vascular Surgery, Changhai Hospital, Navy Medical University, Shanghai, China.
Front Cardiovasc Med. 2022 Mar 9;9:821260. doi: 10.3389/fcvm.2022.821260. eCollection 2022.
Notwithstanding that unprecedented endovascular progress has been achieved in recent years, it remains unclear what is the best strategy to preserve the blood perfusion of abdominal visceral arteries and promote positive aortic remodeling in patients with distal dilatation of chronic aortic dissection in abdominal visceral part (CADAV) after aortic repair. The present study developed a Road Block Strategy (RBS) to solve this conundrum.
This prospective single-center clinical study included patients suffering from symptomatic distal dilatation of CADAV after aortic repair treated with RBS from January 2015 to December 2019 and followed up regularly for at least 2 years. Stent grafts were implanted first to cover distal tears and expand the true lumen. Device embolization was performed to induce proximal and distal segmental false lumen thrombosis (FLT) apart from the level of the ostia of vital branches. Successful RBS was performed in 13 patients. Significant differences were found in maximum true lumen diameter ( < 0.05), blood flow area in false lumen (FL) ( < 0.001), and the ratio of blood lumen to FL area ( < 0.05) between the pre-procedure and the latest follow-up results. No aortic rupture, vital branches occlusion, thoracic and abdominal pain, or death occurred during hospitalization and follow-up.
Our findings suggest that RBS is feasible in treating distal dilatation of chronic aortic dissection after prior proximal repair, inducing false lumen thrombosis, preventing deterioration of aortic dissection, and maintaining the patency of abdominal visceral arteries.
尽管近年来血管内治疗取得了前所未有的进展,但对于腹主动脉慢性夹层(CADAV)远端扩张患者在主动脉修复后,如何最佳地保留腹内脏器动脉的血流灌注并促进主动脉正向重塑仍不清楚。本研究提出了一种路障策略(RBS)来解决这一难题。
这项前瞻性单中心临床研究纳入了2015年1月至2019年12月期间接受RBS治疗的主动脉修复术后出现症状性CADAV远端扩张的患者,并进行了至少2年的定期随访。首先植入支架移植物以覆盖远端破口并扩张真腔。除重要分支开口水平外,进行器械栓塞以诱导近端和远端节段性假腔血栓形成(FLT)。13例患者成功实施了RBS。术前与最新随访结果之间在最大真腔直径(<0.05)、假腔血流面积(<0.001)以及血流腔与FL面积之比(<0.05)方面存在显著差异。住院和随访期间未发生主动脉破裂、重要分支闭塞、胸腹痛或死亡。
我们的研究结果表明,RBS在治疗既往近端修复后的慢性主动脉夹层远端扩张、诱导假腔血栓形成、预防主动脉夹层恶化以及维持腹内脏器动脉通畅方面是可行的。