肌少症各组分与男性骨质疏松性骨折研究（MrOS）中骨折风险的相关性。
Associations of components of sarcopenia with risk of fracture in the Osteoporotic Fractures in Men (MrOS) study.
机构信息
Department of Epidemiology Graduate School of Public Health University of Pittsburgh, Pittsburgh, PA, USA.
VA Boston Healthcare System, Boston, MA, USA.
出版信息
Osteoporos Int. 2022 Aug;33(8):1815-1821. doi: 10.1007/s00198-022-06390-2. Epub 2022 Apr 5.
UNLABELLED
Our aim was to evaluate the associations between the individual components of sarcopenia and fracture types. In this cohort, the risk of experiencing any clinical, hip, or major osteoporotic fracture is greater in men with slow walking speed in comparison to normal walking speed.
INTRODUCTION
The association between the components of sarcopenia and fractures has not been clearly elucidated and has hindered the development of appropriate therapeutic interventions. Our aim was to evaluate the associations between the individual components of sarcopenia, specifically lean mass, strength, and physical performance and fracture (any fracture, hip fracture, major osteoporotic fracture) in the Osteoporotic Fractures in Men (MrOS) study.
METHODS
The Osteoporotic Fractures in Men study (MrOS) recruited 5995 men ≥ 65 years of age. We measured appendicular lean mass (ALM) by dual-energy X-ray absorptiometry (low as residual value < 20th percentile for the cohort), walking speed (fastest trial of usual pace, values < 0.8 m/s were low), and grip strength (max score of 2 trials, values < 30 kg were low). Information on fractures was assessed tri-annually over an average follow-up of 12 years and centrally adjudicated. Cox proportional hazard models estimated the hazard ratio (HR) (95% confidence intervals) for slow walking speed, low grip strength, and low lean mass.
RESULTS
Overall, 1413 men had a fracture during follow-up. Slow walking speed was associated with an increased risk for any HR = 1.39, 1.05-1.84; hip HR = 2.37, 1.54-3.63; and major osteoporotic, HR = 1.89, 1.34-2.67 in multi-variate-adjusted models. Low lean mass and low grip strength were not significantly associated with fracture.
CONCLUSIONS
In this cohort of older adult men, the risk of experiencing any, hip, or major osteoporotic fracture is greater in men with slow walking speed in comparison to men with normal walking speed, but low grip strength and low lean mass were not associated with fracture.
目的
评估肌少症各组分与骨折类型之间的相关性。在本队列中，与行走速度正常的男性相比，行走速度较慢的男性发生任何临床、髋部或主要骨质疏松性骨折的风险更高。
简介
肌少症各组分与骨折之间的相关性尚不清楚，这阻碍了适当治疗干预措施的制定。我们旨在评估肌少症各组分（即瘦体重、力量和身体机能）与男性骨质疏松性骨折（MrOS）研究中的骨折（任何骨折、髋部骨折、主要骨质疏松性骨折）之间的相关性。
方法
男性骨质疏松性骨折（MrOS）研究招募了 5995 名年龄≥65 岁的男性。我们通过双能 X 射线吸收法（低：剩余值< 队列第 20 百分位数）测量四肢瘦体重（ALM），通过最快常速步行试验（速度<0.8m/s 为低）测量行走速度，通过最大握力（2 次试验的最高得分，<30kg 为低）测量握力。骨折信息在平均 12 年的随访中每 3 年进行一次评估，并进行中心审查。Cox 比例风险模型估计了慢步行速度、低握力和低瘦体重与风险比（HR）（95%置信区间）之间的相关性。
结果
在随访期间，共有 1413 名男性发生了骨折。在多变量调整模型中，与行走速度正常的男性相比，行走速度较慢的男性发生任何骨折的风险更高（HR=1.39，1.05-1.84）；髋部骨折（HR=2.37，1.54-3.63）；主要骨质疏松性骨折（HR=1.89，1.34-2.67）。低瘦体重和低握力与骨折无显著相关性。
结论
在本队列的老年男性中，与行走速度正常的男性相比，行走速度较慢的男性发生任何、髋部或主要骨质疏松性骨折的风险更高，而握力较低和瘦体重较低与骨折无关。
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