断裂-融合-桥循环中的断裂：一个80年的谜团。
Breakage in breakage-fusion-bridge cycle: an 80-year-old mystery.
作者信息
Guérin Thomas M, Marcand Stéphane
机构信息
Université Paris-Saclay, Université de Paris, Inserm, CEA, Institut de Biologie François Jacob, iRCM, UMR Stabilité Génétique Cellules Souches et Radiations, Fontenay-aux-Roses, France; Current address: Chromosome Segregation Laboratory, The Francis Crick Institute, London, UK.
Université Paris-Saclay, Université de Paris, Inserm, CEA, Institut de Biologie François Jacob, iRCM, UMR Stabilité Génétique Cellules Souches et Radiations, Fontenay-aux-Roses, France.
出版信息
Trends Genet. 2022 Jul;38(7):641-645. doi: 10.1016/j.tig.2022.03.008. Epub 2022 Apr 6.
2021 marked the 80th anniversary of Barbara McClintock's pioneering article on the breakage-fusion-bridge (BFB) cycle. Of the three steps of the BFB cycle, breakage remains the least understood despite its major contribution to mutagenesis. We discuss recent findings shedding light on how chromatin bridges break in yeast and animal cells.
2021年是芭芭拉·麦克林托克发表关于断裂-融合-桥接（BFB）循环的开创性文章80周年。在BFB循环的三个步骤中，尽管断裂对诱变有重大贡献，但人们对其了解最少。我们讨论了最近的研究结果，这些结果揭示了酵母和动物细胞中染色质桥是如何断裂的。
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