结构性长时程增强：树突棘的信号转导、肌动蛋白细胞骨架重组及膜重塑

Structural LTP: Signal transduction, actin cytoskeleton reorganization, and membrane remodeling of dendritic spines.

作者信息

Yang Yanrui, Liu Jia-Jia

机构信息

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.

出版信息

Curr Opin Neurobiol. 2022 Jun;74:102534. doi: 10.1016/j.conb.2022.102534. Epub 2022 Apr 7.

DOI:10.1016/j.conb.2022.102534

PMID:35398661

Abstract

Induction of long-term synaptic potentiation (LTP) in excitatory neurons triggers a transient enlargement of dendritic spines followed by decay to sustained size expansion, a process termed structural LTP which contributes to the cellular basis of learning and memory. The activity-induced structural changes in dendritic spines involve spatiotemporal coordination of actin cytoskeleton reorganization, membrane trafficking and membrane remodeling. In this review, we discuss recent progresses in understanding the complex mechanisms underlying structural LTP, with an emphasis on the interplay between the spine plasma membrane and the actin cytoskeleton. We also highlight open questions and challenges to further understand this interesting cell neurobiological phenomenon.

摘要

兴奋性神经元中长时程突触增强（LTP）的诱导会触发树突棘的短暂增大，随后衰减至持续的大小扩张，这一过程称为结构性LTP，它有助于学习和记忆的细胞基础。活动诱导的树突棘结构变化涉及肌动蛋白细胞骨架重组、膜运输和膜重塑的时空协调。在这篇综述中，我们讨论了在理解结构性LTP潜在复杂机制方面的最新进展，重点是棘突质膜与肌动蛋白细胞骨架之间的相互作用。我们还强调了有待解决的问题和挑战，以进一步理解这一有趣的细胞神经生物学现象。