在单细胞中绘制染色质环。
Mapping chromatin loops in single cells.
机构信息
State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Department of Genetics, University of North Carolina, Chapel Hill, NC, USA; Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA; Department of Computer Science, University of North Carolina, Chapel Hill, NC, USA.
出版信息
Trends Genet. 2022 Jul;38(7):637-640. doi: 10.1016/j.tig.2022.03.007. Epub 2022 Apr 7.
Abstract
Recent advances in high-throughput chromatin conformation capture (Hi-C) technologies at the single-cell level enable the identification of cell type-specific chromatin loops directly from complex tissues. This may help to interpret noncoding variants identified by genome-wide association studies (GWAS) in disease-relevant cell types. We briefly review current experimental and computational strategies for mapping chromatin loops in single cells.
摘要
单细胞水平高通量染色质构象捕获（Hi-C）技术的最新进展使我们能够直接从复杂组织中鉴定出特定于细胞类型的染色质环。这可能有助于解释在疾病相关细胞类型中通过全基因组关联研究（GWAS）鉴定的非编码变体。我们简要回顾了当前用于在单细胞中绘制染色质环的实验和计算策略。
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